TRAFFICKING OF METABOLITES BETWEEN M LLER CELLS AND NEURONS IN DIABETIC RETINOPATHY.

糖尿病是导致工作人群失明的主要原因。在一些糖尿病患者中，视网膜内的血管增生、出血或导致视网膜脱离。视网膜内导致血管增生的潜在变化尚未得到很好的理解。导致视网膜血管变化的因素之一是来自视网膜中称为Muller细胞的细胞的生长因子的增加。米勒细胞对视网膜的正常功能至关重要，并且已知在糖尿病晚期是异常的。它们也可能在糖尿病早期功能失调，并可能在糖尿病的早期变化中发挥重要作用。因此，很好地理解穆勒细胞如何变化以及它们变化的时间对于更好地理解与糖尿病相关的缺陷至关重要。此外，了解糖尿病中发生的基本细胞变化将有助于未来开发更特异性的治疗药物。

Diabetes is the leading cause of blindness in the working population. In some diabetics, blood vessels within the retina proliferate, haemorrhage or cause retinal detachment. The underlying changes within the retina that lead to the proliferation of blood vessels are not well understood. One of the factors that leads to changes in retinal blood vessels is an incease in growth factors from cells in the retina called Muller cells. Muller cells are vital for the normal function of the retina, and are known to be abnromal late in diabetes. They may also be dysfunctional early in diabetes and could play a significant role in the early chnages seen in diabetes. Therefore a good understanding of how Muller cells change and the time at which they change is vitally important to gain a better undetrstanding of the defects that are associated with diabetes. Furthermore, an understanding of the basic underlying cellular changes that occur in diabetes will aid the development of more specific therapeutic agents in the future.