Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
批准号:
nhmrc : GNT1101552
负责人:
A/Pr Chrishan Samuel
金额:
$104.93万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
与年龄匹配的男性相比,女性免受心血管疾病的保护,这一效果随着年龄的增长而消失。了解作用于女性的保护性因素可用于治疗所有年龄段男性的高血压、心力衰竭和中风,并维持老年女性的保护。我们的研究旨在确定松弛素,一种卵巢激素,是否可以促进女性的心血管健康。
英文摘要
Women are protected from cardiovascular disease as compared to age-matched men, an effect lost with age. Understanding protective factors that act in females could be used to treat hypertension, heart failure and stroke in males at all ages, and maintain protection in elderly women. Our studies aim to determine if relaxin, an ovarian hormone, can promote cardiovascular health in women.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
-
批准号:nhmrc : GNT1146049
-
项目类别:Project Grants
-
资助金额:$103.64万
-
财政年份:2018
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
-
批准号:nhmrc : 1146049
-
项目类别:Project Grants
-
资助金额:$70.07万
-
财政年份:2018
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
-
批准号:nhmrc : GNT1122170
-
项目类别:Project Grants
-
资助金额:$79.86万
-
财政年份:2017
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
-
批准号:nhmrc : 1122170
-
项目类别:Project Grants
-
资助金额:$54.45万
-
财政年份:2017
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
-
批准号:nhmrc : 1101552
-
项目类别:Project Grants
-
资助金额:$72.15万
-
财政年份:2016
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
-
批准号:nhmrc : 1078694
-
项目类别:Project Grants
-
资助金额:$25.27万
-
财政年份:2015
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
-
批准号:nhmrc : GNT1078694
-
项目类别:Project Grants
-
资助金额:$36.71万
-
财政年份:2015
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Developing Relaxin Peptides as Novel Therapies for Fibrosis
-
批准号:nhmrc : 1041766
-
项目类别:Research Fellowships
-
资助金额:$50.1万
-
财政年份:2013
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Developing Novel Therapies for Fibrosis
-
批准号:nhmrc : GNT1041766
-
项目类别:Research Fellowships
-
资助金额:$59.08万
-
财政年份:2013
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Relaxin therapy reverses large artery remodelling and stiffening in aged and hypertensive models
-
批准号:nhmrc : 1004235
-
项目类别:Project Grants
-
资助金额:$29.67万
-
财政年份:2011
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Molecular mechanisms of renal fibrosis
-
批准号:nhmrc : 628634
-
项目类别:NHMRC Project Grants
-
资助金额:$25.0万
-
财政年份:2010
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Novel Candidate Genes, Lung Function and Allergic Airways Disease
-
批准号:nhmrc : 546428
-
项目类别:NHMRC Project Grants
-
资助金额:$38.8万
-
财政年份:2009
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
Investigating the anti-fibrotic properties of relaxin in the normal and diseased heart
-
批准号:nhmrc : 454636
-
项目类别:Career Development Fellowships
-
资助金额:$31.95万
-
财政年份:2007
-
负责人:A/Pr Chrishan Samuel
-
依托单位:
海外基金