Understanding the development of autoimmunity in response to citrullinated peptide antigen presentation to T cells in rheumatoid arthritis

类风湿关节炎(RA)是一种全身性自身免疫性疾病，主要影响滑膜关节，在全世界1%的成年人中。人类白细胞抗原II类基因是类风湿关节炎的主要遗传易感基因。该工作计划汇集了来自3个国家的7名研究人员，以确定在高加索人、亚洲人和北美土著人口中，具有类风湿性关节炎遗传风险的个人如何发展对自身抗原的自身免疫，以及为什么抗性等位基因对类风湿性关节炎具有保护作用。我们将提供一种分子

Rheumatoid arthritis (RA) is a systemic autoimmune disease predominantly affecting synovial joints, in 1% of adults worldwide. HLA-class II genes underlie the major genetic susceptibility to RA. The programme of work brings together 7 investigators from 3 countries to determine how autoimmunity develops to self antigens in individuals at genetic risk of RA and why resistance alleles are protective against RA, in Caucasian, Asian and North American Native populations. We will provide a molecular