Understanding the role of the scaffolding protein D13 in poxvirus assembly and its inhibition by rifampicin

天花是人类历史上最臭名昭著的疾病之一。尽管在20世纪70年代消灭了天花，但猴痘病毒等动物天花病毒的人类病例以及天花作为生物恐怖主义武器的潜在用途要求澳大利亚加强对(重新)出现的天花病毒的准备。该项目结合结构生物学方法了解痘病毒的复杂组装，为开发广谱抗病毒药物提供基础。

Smallpox is one the most notorious diseases in human history. Despite its eradication in the 1970s, human cases of animal poxviruses such as monkeypox virus and the potential use of smallpox as a bioterrorism weapon have called for an improved preparedness of Australia against (re)-emerging poxviruses. This project combines structural biology approaches to understand the complex assembly of poxviruses and provide the basis for the development of broad-spectrum antiviral drugs.