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Virological determinants of drug resistance in real-world patients with chronic HCV infection

Virological determinants of drug resistance in real-world patients with chronic HCV infection
现实世界慢性 HCV 感染患者耐药性的病毒学决定因素
批准号:
nhmrc : 1066537
负责人:
A/Pr Fabio Luciani
金额:
$36.72万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

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中文摘要
翻译
丙型肝炎病毒(HCV)感染的新治疗方法正在出现。这些药物直接针对病毒生命周期中的关键事件。虽然这些药物是有效的,但丙型肝炎病毒的变异能力意味着可能产生耐药性,导致治疗失败。这种情况最可能发生在对干扰素治疗无反应的患者身上。这项提议将使用新的、高度敏感的测序方法来确定导致耐药性的病毒突变和进化途径。
英文摘要
New treatments for hepatitis C virus (HCV) infection are emerging. These drugs directly target key events in the viral life cycle. While these drugs are effective, the ability of HCV to mutate means that drug resistance can arise, leading to treatment failure. This is most likely in patients who do not respond to interferon-based therapy. This proposal will use new, highly sensitive sequencing approaches to identify the viral mutations and evolutionary pathways that lead to drug resistance.
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