Virulence determinants of encephalitic flaviviruses
Virulence determinants of encephalitic flaviviruses
批准号:
nhmrc : 456126
负责人:
Prof Alexander Khromykh
金额:
$30.38万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2009-12-31
中文摘要
墨累谷脑炎、日本脑炎病毒和西尼罗河病毒是蚊子传播的病原体,会在人和动物中引起严重和致命的神经疾病。目前,尚不清楚为什么这些病毒会产生如此严重的疾病,因此它们很难治疗和预防。在这个项目中,我们将识别病毒的成分,这些病毒允许它们入侵中枢神经系统并导致神经症状。这将提供关于这些致病病毒的关键成分的宝贵信息,这些关键成分有助于它们的毒力,并将确定用于预防它们引起的脑炎疾病的新的候选疫苗。
英文摘要
Murray Valley encephalitis, Japanese enecephaltis virus and West Nile virus are mosquito transmitted pathogens that cause severe and fatal neurological diseases in man and animals. Currenly, it is not clear why these viruses produce such severe diseases and therefore they are difficult to treat and prevent. In this project we will indentify the components of the viruses that allow them to invade the central nervous sytem and cause neurological symptoms. This will provide valuable information on critical elements of these pathogenic viruses that contribute to their virulence and will identify new candidate vaccines for prevention of the encephalitic diseases they cause.
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