300 MHz NMR console for research in molecular synthesis, heteronuclear experiments, and kinetics experiments

核磁共振波谱是化学家可用于表征化合物、材料和生物系统的最通用的技术之一。事实上，核磁共振波谱是化学研究中不可或缺的工具。这项技术被用来确定分子结构，监测化学反应速度，研究动态过程等。核磁共振波谱在化学中的应用几乎是无限的，包括：有机合成、生物有机化学、生物化学、无机化学、有机金属化学、催化、材料科学、储氢和绿色化学。在这项提案中，迫切需要资金来升级渥太华大学300兆赫核磁共振光谱仪的控制台。目前的游戏机已经有十年的历史了，在过去的一年里经历了漫长的故障。这种故障对20名教职员工和100名研究生和博士后研究员的研究项目产生了严重的负面影响。随着我们部门最近的扩张，这些影响将变得更加成问题。所要求的控制台升级将使在分子合成和催化等一般领域的几个不同研究项目中进行尖端研究。核磁共振光谱仪的特殊用途包括但不限于：(I)学生和受训人员可立即进入；(Ii)异核核磁共振实验(例如碳-13、磷-31、硼-11)；(Iii)动手使用和培训最先进的光谱仪上的高素质人员；(Iv)表征化学反应动力学的长期实验；(V)变温实验；(Vi)对不稳定和对空气敏感的样品进行实验。

Nuclear magnetic resonance (NMR) spectroscopy is one of the most versatile techniques available to chemists to characterize compounds, materials, and biological systems. In fact, NMR spectroscopy is an indispensible tool in chemical research. The technique is used to determine the structures of molecules, to monitor the rates of chemical reactions, to study dynamic processes, and much more. There is a practically infinite number of applications of NMR spectroscopy in chemistry, including those in: organic synthesis, bioorganic chemistry, biological chemistry, inorganic chemistry, organometallic chemistry, catalysis, materials science, hydrogen storage, and green chemistry. In this proposal, funding is urgently requested to upgrade the console of a 300 MHz NMR spectrometer at the University of Ottawa. The current console is ten years old and has suffered lengthy breakdowns over the past year. Such breakdowns have severe negative impacts on the research programs of 20 faculty members and 100 graduate students and postdoctoral-fellows. These impacts will become more problematic with the recent expansion of our department. The requested console upgrade will enable cutting-edge research in several diverse research programs in the general areas of molecular synthesis and catalysis. Particular uses of the NMR spectrometer include, but are not limited to: (i) immediate walk-up access for students and trainees; (ii) heteronuclear NMR experiments (e.g., carbon-13, phosphorus-31, boron-11); (iii) hands-on use and training of highly-qualified personnel on a state-of-the art spectrometer; (iv) long experiments to characterize chemical reaction kinetics; (v) variable-temperature experiments; (vi) experiments on unstable and air-sensitive samples.