A systems-level study of the mechanisms leading to RAF dimerization and activation
A systems-level study of the mechanisms leading to RAF dimerization and activation
批准号:
256051
负责人:
Lavoie Hugo
金额:
$6.56万
依托单位国家:
加拿大
项目类别:
Fellowship Programs
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-02-01 至 2014-02-01
中文摘要
RAS/ERK信号通路的过度激活是导致肿瘤发生和发展的关键事件之一。这条通路中的信号传递需要三个核心激酶(raf、mek和erk)的正确组装,它们通过ph传递传入信号。
英文摘要
Hyperactivation of RAS/ERK signaling is among the key events leading to tumor initiation and progression. Signaling within this pathway requires the proper assembly of three core kinases (RAF, MEK and ERK) that convey incoming signals by the means of a ph
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A systems-level study of the mechanisms leading to RAF dimerization and activation
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批准号:247500
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项目类别:Fellowship Programs
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资助金额:$10.2万
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财政年份:2011
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负责人:Lavoie Hugo
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依托单位:
海外基金