UV-visible Spectrophotometer

该提案旨在募集资金，以便西蒙弗雷泽大学的研究人员可以用高质量的研究仪器取代目前不起作用的“紫外可见分光光度计”。为了理解化学和生物化学反应，有必要测量反应速率，或这些过程发生的速度。紫外线和/或可见光通过含有我们正在研究其反应的化合物的溶液，光谱仪测量随着反应进行的光的变化。这种技术使我们能够监视以几十秒到几天的速率发生的进程。研究人员将使用该设备来回答有关以下关系的基本问题：(i)蛋白质的结构和功能；（ii）酶催化反应的机理；（三）关于生物分子在没有酶的情况下反应速度的问题。研究人员获得的结果将对许多生物过程和疾病状态产生影响。

This proposal aims to solicit funds so that researchers at Simon Fraser University can replace a currently non-functional "UV-vis Spectrophotometer" with a top-quality research instrument. In order to understand chemical and biochemical reactions it is necessary to measure the rate of reaction, or how fast these processes occur. Ultra-violet and/or visible light is passed through a solution containing the compounds whose reaction we are studying and the spectrometer measures the changes in light as the reaction progress. This technique enables us to monitor processes that occur at rates between tens of seconds to several days. The investigators will use the equipment to answer fundamental question concerning relationships between: (i) the structure and function of proteins; (ii) the mechanisms of enzyme-catalyzed reactions; and (iii) questions concerning the speed at which biomolecules can react in the absence of enzymes. The results that are obtained by the investigators will have implications for numerous biological processes and disease states.