Development of low-cost, rapid and highly sensitive DNA-based biosensor for routine monitoring of emerging organic compounds in water

我们的目标是开发一种创新的高通量筛选传感平台，用于检测和监测饮用水系统中新出现的有机污染物(EOCs)。EOCs对应于一组新检测到的具有潜在健康危害的污染物。当局担心这些新污染物对公众健康的潜在影响，因为它们正在寻找进入不同饮用水系统的途径。在这些污染物中，有几类与公众健康特别相关的化合物：抗生素、激素和其他干扰内分泌的化合物。对这些化合物的高灵敏度检测方法的需求很高，因为它们只存在于痕量。目前水中EOCs的检测方法严重依赖昂贵的分析仪器和冗长的生物学方法，不适合常规的现场监测。我们在这里提出了一项研究计划，旨在用一种优雅的、成本效益高的检测系统来取代目前的检测方法。这个系统能够

We are aiming to develop an innovative highthroughput screening sensing platform for the detection and monitoring of Emerging Organic Contaminants (EOCs) in drinking water systems. EOCs correspond to a group of newly detected contaminating compounds with potential health hazards. Authorities are concerned about the potential public health impact of these new contaminants as they are finding their way into different drinking water systems. Among these contaminants are several families of compound that are particularly relevant to public health: antibiotics, hormones and other endocrine disrupting compounds. Highly sensitive detection methods for these compounds are in high demand as they are present only in trace amounts. Current detection methods for EOCs in water rely heavily on expensive analytical instruments and lengthy biological methods that are not suitable for routine field monitoring. We propose here a research program aiming to replace the current detection methodologies with an elegant, cost-effective detection system. This system is capable of