"Multimodal Optical Imaging Endoscopy for Noninvasive ""Optical Biopsy"" in Tissues"

肺癌是加拿大癌症死亡的首要原因。2011年，肺癌估计占男性癌症死亡人数的11，300人和女性癌症死亡人数的9，300人。早期发现和治疗有可能大大改善这些统计数据。目前癌症诊断的金标准是组织活检，然后是组织病理学。在这个过程中，临床医生从可疑区域进行多个组织活检，并进行组织病理学检查。该过程是侵入性的且耗时。“光学活检”是一种利用光学成像技术对活体亚细胞组织形态进行检查的新型工具。它可以提供与组织病理学相同的成像分辨率，但该过程是非侵入性的，并且是实时的。因此，“光学活检”可能对癌症和其他疾病的诊断和治疗产生巨大影响。

Lung cancer is the foremost cause of cancer death in Canada. In 2011, lung cancer is estimated to account for 11,300 of cancer deaths in men and 9,300 in women. Early detection and treatment has the potential to greatly improve these statistics. The current gold standard of cancer diagnosis is tissue biopsy followed by histopathology. In this procedure, clinicians take multiple tissue biopsies from suspicious areas and perform histopathology examination. This procedure is invasive and time consuming. "Optical biopsy" is a new type of tool which uses optical imaging to examine subcellular tissue morphology in vivo. It can provide the same imaging resolution as histopathology but the procedure is noninvasive and in real-time. Therefore, "optical biopsy" can potentially have a huge impact on the diagnosis and treatment of cancer and other diseases.