Metal mediated and catalyzed organic synthetic methods

本研究的目的是开发和理解一系列由过渡金属配合物介导或由过渡金属配合物或主基团化合物催化的新型有机化学反应。目标包括开发碳-碳键形成反应的类型，通常不容易通过传统的有机化学过程完成（即，反应性模式相对于大多数有机化合物是倒置的），并制备和使用如果没有金属单元的存在通常不可能存在的化合物。特别地，所提出的铟、铑和铱催化的烯丙化反应，连同其他催化反应，被设计为提供这种反向反应性模式的催化方法。所提出的炔内二钴配合物的设计是为了使没有钴就无法分离的化合物的使用成为可能。

The objective of the proposed research is to develop and understand a series of novel organic chemical reactions mediated by transition metal complexes or catalyzed by either transition metal complexes or main group compounds. The goals include the development of types of carbon-carbon bond forming reactions not normally readily accomplished by traditional organic chemical processes (i.e., the pattern of reactivity is inverted relative to most organic compounds), and to prepare and use compounds that could not normally exist if it were not for the presence of the metal unit. In particular the proposed indium, rhodium, and iridium catalyzed allylation reactions, in conjunction with other catalytic reactions, are designed for being catalytic methods of giving this inverted pattern of reactivity. The proposed alkynedicobalt complexes are designed to make possible the use of compounds that could not be isolated if not for the cobalt.