Motion of the charged droplets and ions in mass spectrometers

该建议旨在提高质谱仪（MS）的灵敏度。 这将通过模拟离子流经MS的各个部分来实现，这些部分负责离子的形成和传输。目的是提高离子电流，以最大限度地减少损失和最大限度地提高质量。我们将使用气流阻力和电场的组合来模拟离子运动。我们预计显着改善的信号噪声比，从而使大大降低量化水平。 我们还预计在质谱的离子运动控制的基础上，使用流和电场的新技术的发展。 该项目与Ionics Mass Spectrometry Group Inc.合作。这项研究的结果将有可能使Ionics成为行业领先的高灵敏度MS的唯一制造商。他们的客户将受益于使用更小的样品和增加他们的吞吐量。公共部门受益，因为实验室能够更快、更频繁地提供健康结果，从而提高对药物、食品、饮料和环境保护等可摄入消费品的质量控制。

This proposal is aimed at improving sensitivity of mass spectrometers (MS). This will be achieved by modeling the ion flow through various parts of a MS which are responsible for ion formation and transportation. The objective is to improve the ion current in order to minimize losses and maximize quality. We will use a combination of gas flow drag and electric field to model the ionic motion. We anticipate significant improvement in the signal-to-noise ratio, thereby enabling substantially lower levels of quantization. We also anticipate development of new technologies in the mass spectrometry based on the ion motion control, using both flow and electric field. This project is in collaboration with Ionics Mass Spectrometry Group Inc. The results of this study will potentially allow Ionics to secure an industry lead positioned as the only manufacturer of a highly sensitive MS. Their customers would benefit by using much smaller samples and increasing their throughput. The public sector benefits as laboratories are able to deliver health results faster and more frequently, leading to higher quality control on ingestible consumables, such as drugs, food, beverages, and environmental protection.