Innate immunity of teleosts

我的研究计划和目前短期目标中概述的研究旨在更好地了解鱼类对传染病的先天抵抗力。水产养殖占全世界鱼蛋白消费量的一半，传染病是造成产量损失的一个重要原因。水产养殖是加拿大的一个增长型产业，未来将继续扩大并支持加拿大的就业。鱼类健康的成本效益比（单位产品相对较低的成本）要求我们确定对传染病的先天抗性标记，以提高存活率，而不严重依赖抗菌剂或昂贵的产品。我们已经使用功能结合试验来鉴定与细菌和病毒结合的血清蛋白。我们已经确定了极有可能与特定病原体抗性相关的蛋白质，这项研究将解决鱼类识别和消除传染性病原体的一些机制。现在，我们希望研究其中一种蛋白质，即智联蛋白，在抵抗

My research program and the studies outlined in the present short-term objectives are designed to better understand innate resistance of fish to infectious disease. Aquaculture is responsible for up to half of all fish protein consumed worldwide and infectious disease is an important cause of lost production. Aquaculture is a growth industry for Canada and will continue to expand and support Canadian jobs in the future. The cost-benefit ratio (relatively low cost per unit product) for fish health requires that we identify innate markers for resistance to infectious disease to provide enhanced survival, without heavy reliance on antimicrobials or expensive products. We have used functional binding assays to identify serum proteins that bind to bacteria and virus. We have identified proteins that are highly likely relevant for resistance to specific pathogens and this research will address some of the mechanisms by which fish recognize and eliminate infectious agents. We now wish to examine specific roles of one of these proteins, intelectin, in resistance to