Self Sustaining Scaffolds

在全球范围内，数百万人死亡，截肢或遭受功能丧失，因为他们体内估计有20亿至500亿毛细血管中的一些停止正常运作。支架植入术、外科手术和药剂学的最新进展有助于分流、打开和防止小直径动脉闭合，挽救了无数生命。 在小动脉-小静脉的尺度或以下，脉管系统可以快速再生，但科学对如何有目的地引导或增强这种先天力量以诱导增强再生的理解很少。 患者只需等待足够的愈合发生并避免感染。 由于高龄、糖尿病和血管疾病导致愈合不良，导致并发症，如术后死亡率增加、干预失败和住院时间延长。最先进的是一种简单的真空敷料，可以阻止液体积聚，帮助减少感染，从而加速愈合，或者在可行的情况下使用高压氧舱。申请人想到，在改善氧扩散进入多孔电极和废物流出多孔电极以构建燃料电池供电的未来方面的巨大努力也可以应用于可能潜在地复制毛细管的一些功能的装置。持续氧输送过氧化物分解复合物的初步数据非常令人鼓舞，例如防止血管化不良伤口中的组织坏死和损失，维持无血管组织活力足够长时间以使17 mm厚移植物血管再通，以迄今不可能的密度培养细胞3天：（1.5 mm直径球体，密度2 × 105）

Globally, millions of people die, undergo amputation or suffer loss of function because some of the estimated 2-50 billion capillaries in their bodies cease to function normally. Recent advances in stenting, surgery and phamaceutics have helped bypass, open and prevent closure of small diameter arteries saving countless lives. At or below the scale of arterioles - venules the vasculature can regenerate rapidly but science has little understanding of how to purposefully direct or enhance this innate power to induce augmented regeneration. Patients simply wait for adequate healing to occur and avoid infection. Poor healing due to advanced age, diabetes and vascular disease, leads to complications such as increased post surgical mortality, failure of interventions and prolonged hospital stays. State of the art is a simple vacuum dressing that can stop fluid build up, help reduce infection and thereby accelerate healing or where feasible a hyperbaric oxygen chamber. It occurred to the applicant that the huge effort in improving oxygen diffusion into and waste out of porous electrodes to build the fuel cell powered future could also be applied to devices that could potentially replicate some of the functions of capillaries. Preliminary data with sustained oxygen delivery peroxide decomposition composites were highly encouraging such as preventing necrosis and loss of tissue in a poorly vascularized wound, maintaining avascular tissue viability long enough for revasuclarisation of a 17mm thick graft, culturing cells for 3 days at hitherto impossible densities: (1.5mm diameter spheres, density 2 x10