A collaboration between the University of Ottawa and Vivosonic towards the use of the Integrity V500 in the quantitative evaluation of tinnitus

目前，Vivosonic(合作伙伴)制造了IntegrityTM V500，这是市场上独一无二的系统，因为它能够在不太理想的临床环境中获取听觉脑干反应。该系统目前被用于识别非器质性听力损失，使用一种客观的方法，即使在难以测试的患者中也可以进行准确的测量。拟议的项目旨在通过创建一种使用噪声间隙范式客观识别耳鸣的新协议来进一步扩展该产品的能力。目前，用于耳鸣检测的噪声间隙方法已经在小鼠身上得到验证(Lowe等人。2015年)；由于缺乏现有技术，它在人类身上的应用被排除在外。目前诊断耳鸣的方法是主观的和基于行为的；这限制了定量评估，并阻止了对难以测试的人群的评估，如儿科患者和发育障碍患者。

Currently, Vivosonic (the Partner) manufactures the IntegrityTM V500, a system unique to the market for itsability to acquire auditory brainstem responses in less-than-ideal clinical environments. This system is currentlyused to identify non-organic hearing loss using an objective method that allows accurate measurements even indifficult-to-test patients.The proposed project aims to further extend the capability of this product by creating a novel protocol toobjectively identify tinnitus, using a gap-in-noise paradigm. Currently the gap-in-noise method for tinnitusdetection has been validated on mice (Lowe et al. 2015); its application to humans has been precluded due tolack of existing technology. Current methods to diagnose tinnitus are subjective and behavioral-based; thislimits quantitative evaluation and prevents assessment in difficult-to-test populations, such as paediatricpatients and patients with developmental disabilities.