MS detector to replace previous LCMS detector damaged in a catastrophic electrical fire

我们迫切需要为我们的主力LC-MS系统更换一个电喷雾电离质谱仪(MS)。LC-MS分析通常由我们研究小组中的每个HQP每天进行，以检测和表征生化反应、细菌培养或体内代谢物捕获的复杂分子。我们之前的MS探测器经历了灾难性故障(电气起火)，对所有HQP的培训和学位进步产生了负面影响。没有可比的工具有足够的可获得性或可负担性来取代这一重要的研究工具。如果没有这些基础设施，Boddy实验室将无法维持其在利用天然产物生物合成来获取复杂分子方面的国际公认的尖端研究计划，舒亨德勒实验室也将无法实施其体内捕获活性药物代谢物的革命性计划。

We desperately require a replacement electrospray ionization mass spectrometer (MS) for our workhorse LC-MS system. LC-MS analysis is typically performed daily by each HQP in our research groups to detect and characterize complex molecules from biochemical reactions, bacterial cultivations, or in vivo metabolite trapping. Our previous MS detector experienced catastrophic failure (electrical fire), negatively impacting the training and progress through their degrees for all HQPs. No comparable instrument has sufficient availability or affordability to replace this essential research tool. Without this infrastructure, the Boddy lab will not be able to maintain its internationally recognized, cutting edge research program on harnessing natural product biosynthesis to access complex molecules nor will the Shuhendler lab be able to implement its revolutionary program for in vivo trapping of reactive drug metabolites.