Multimodal sensor arrays for high throughput biological analysis

混合微流体/微电子技术的最新进展使高通量筛选技术的发展能够用于包括药物发现在内的各种应用。在各种竞争的标准集成电路（IC）技术中，互补金属氧化物半导体，通过提供一个独特的成本，集成传感器和电路，是最佳的候选者。该技术已广泛应用于各种应用，如通信，计算机和其他消费电子应用，但最近它已经引起了人们对生命科学应用（如DNA测序和细胞分析）ic开发的关注。尽管取得了很大的进步，但混合CMOS微流体系统在可重复使用性和生物相容性方面仍然受到限制。约克大学与其工业合作伙伴Medella**Health的这项合作研究旨在解决这一挑战，并提供CMOS兼容的解决方案。该公司在改善生物传感器信号转导所需的纳米材料方面取得了重大进展。该项目的短期目标是通过在公司开发的金属纳米颗粒上涂覆，提供一种提高CMOS生物相容性的解决方案。该行业合作伙伴的长期目标是开发一种用于测量细胞活动的新技术，该技术可用于许多应用，包括基于细胞的癌症药物测试。

Recent advances in hybrid microfluidic/microelectronic technologies have enabled the development of**High-Throughput Screening techniques for various applications including drug discovery. Among various**competing standard integrated circuit (IC) technologies, Complementary Metal Oxide Semiconductor, by**offering a distinct cost, integrated sensors and circuits, is the best candidate. This technology has been widely**used in a variety of applications such as communications, computer and other consumer electronic applications,**but very recently it has attracted the attention for the development of ICs for life science applications such as**DNA sequencing and cellular analysis.**Despite great advances, hybrid CMOS microfluidics systems still suffers limitations in their reusability and**biocompatibility. This collaboration research between York University and its industrial partner - Medella**Health will aim to address this challenge and offer a CMOS compatible solution. The company has made**significant advancements in improving the nanomaterial required for transducing the biosensor signal. The**short term goal of this project is to offer a solution to enhance the biocompatibility of CMOS by coating the**metal nanoparticles developed by company. The long-term goal for the industry partner is to develop a new**technology for measuring cellular activities, which can be used for many applications, including cell-based**drug tests for cancer.