Development of an Anti-Viral coating for Pandemic Mitigation of COVID-19 using titanium dioxide nanoparticles

SARS-CoV-2在各种表面上保持活性长达72小时，形成一个受污染的表面网络，使病毒迅速传播。在这个项目中，我们建议通过防止病毒通过表面污染转移来解决这个问题。我们提出设计一种新型的含有TiO 2纳米颗粒的涂层，其在可见光下可以消灭通过微滴或触摸附着在高风险表面上的SARS-CoV-2病毒。这可以显著防止交叉污染和病毒的快速传播。我们将以喷雾和油漆的形式加入光活性TiO 2纳米颗粒，这是两种最常用的表面涂层技术。 因此，这种新型涂层可以简单地应用于各种表面和已经内置的部件，如旋钮、手柄、墙壁、天花板和生物医学仪器。TiO 2颗粒在紫外光照射下具有光催化活性，可以在短时间内光杀死SARS-CoV-2病毒的衣壳蛋白。此外，二氧化钛是一种低成本材料，具有非常低的毒性和高的化学稳定性。为了在可见光下诱导TiO 2纳米颗粒的光催化性能，我们将使用单步热处理技术用氮掺杂颗粒。 与我们的行业合作伙伴（Nanophyll Inc.）我们决心设计一条试验生产线，并以抗病毒涂料或喷雾的形式迅速将我们的最终产品商业化。我们的工业合作伙伴在开发和制造抗菌和防污以及自清洁的智能涂料方面拥有丰富的经验，这将极大地帮助利用Nanophyll战略合作伙伴的潜力快速实现所开发涂料的商业化。

SARS-CoV-2 remains active on various surfaces for up to 72 hours creating a network of contaminated surfaces, enabling rapid spread of the virus. In this project we propose to address this issue by preventing the transition of the virus through surface contamination. we propose to design a new type of coating containing TiO2 nanoparticles which, under visible light, can annihilate the SARS-CoV-2 viruses that are attached to high risk surfaces via microdroplets or touch. This could significantly prevent cross-contamination and rapid spread of the virus. We will incorporate the photoactive TiO2 nanoparticles in the form of sprays and paint which are the two most-commonly used techniques for coating surfaces. Consequently, the new type of coating can simply be applied to a variety of surfaces and already built-in parts such as knobs, handles, walls, ceilings, and biomedical instruments. TiO2 particles are photocatalytically active under UV irradiation and can photo-kill capsid proteins of SARS-CoV-2 viruses in a short time. Moreover, Titania is a low-cost material and possesses very low toxicity and high chemical stability. In order to induce photocatalytic properties in TiO2 nanoparticles under visible light, we will dope the particles with nitrogen using a single-step heat treatment technique. In collaboration with our industry partner (Nanophyll Inc.) we are determined to design a pilot production line and rapidly commercialize our final product in the form of an antiviral paint or spray. Our industrial collaborator's considerable experience in developing and manufacturing smart coatings for bacteria and fouling resistant as well as self-cleaning, will greatly help with rapid commercialization of the developed coatings using the potential of Nanophyll's strategic partners.