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Dissecting the origins and microenvironment of replication repair deficient hypermutant gliomas for novel immune based therapies

Dissecting the origins and microenvironment of replication repair deficient hypermutant gliomas for novel immune based therapies
剖析复制修复缺陷型超突变神经胶质瘤的起源和微环境，用于新型免疫疗法
批准号：
444717
负责人：
Tabori Uri
金额：
$94.74万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-04-01 至 2026-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=444717&lang=en
关键词：
Brain Tumours Cancer Genetics Gliomas Hypermutation Immunotherapy

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中文摘要
翻译
胶质瘤是儿童、青少年和年轻人（CAYA， 0-40岁）中最常见的脑肿瘤，也是这一人群中癌症死亡的主要原因。我们发现其中一些胶质瘤含有最高数量的DNA突变(超
英文摘要
Gliomas are the most common brain tumours in children, adolescents, and young adults (CAYA, 0-40 years) and are a leading cause of cancer death in this population. We discovered that some of these gliomas contain the highest number of DNA mutations (hyper
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Uncovering the mechanism and impact of novel genetic and epigenetic promoter alterations on tissue-specific mismatch repair deficient cancers
Biological and translational implications of replication repair deficiency and hypermutation in human cancer
Translating genomic discoveries to cure ultrahypermutant mismatch repair deficient brain tumors
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