Design, developement and validation of materials and surfaces for innovative biomaterials

在过去的几十年里，生物材料成功地改善了数百万人的生活质量。然而，生物材料和医疗器械完全成功的应用非常罕见。失败或临床并发症经常被观察到，不同的应用有不同的发生率。我提出的研究计划是NSERC的一个发现计划，非常坚实地建立在研究材料科学和工程方面应用于心血管医学领域的基础上。 具体地说，我建议继续并巩固一个新的三块研究计划：1)调查允许开发主要基于等离子体聚合的金属设备的高粘附性和强粘结性涂层的参数；2)设计一种专用于心血管设备的新型可降解金属；以及3)开发用于特定受控生物反应器中机械应力下的材料和细胞的接口的新策略，以用于血管组织的再生。第一块和第二块的总体目标是在短期和中期(1至5年)提供能够改善医疗器械临床性能的新涂层和新材料。区块3的总体目标是产生有针对性的知识和专业知识，能够长期(10至15年)产生用于功能性血管组织再生的具体方法。 拟议的研究计划非常中肯和及时，以满足高素质人才的形成需求，从而满足准确的社会需求和医疗器械行业的挑战。此外，拟议的研究计划将产生一个多价技术平台，易于应用于其他领域和应用，包括制药、防腐、光学、家庭、军事和工业，这些领域和应用需要专门设计的具有目标性能的材料和涂层。我们使用先进的材料科学和工程技术为生物医学挑战提供工程解决方案。 在这项提议中，我们既提高了加拿大的知识水平，又培养了加拿大关键优势领域的高素质人才。我们的研究环境非常出色，特别适应了我们现在面临的新的全球市场时代。自2008年以来，超过100名HQP在我们的实验室接受了培训：如今，他们利用与我们一起接受培训的日常先进知识、领导力、快速适应技能、全球网络联系和战略思维，在学术界、行业和政府部门担任职务。我们的实验室被公认为在科学领域广泛出版和打开新的大门，为新发明申请专利和提出许可证，出席国际会议，与四大洲约20位世界学术界和工业界领袖合作，并向监管政府机构提供建议。

In the last decades, biomaterials have been successful to improve quality of the life for millions. However, very rare are the applications for which biomaterials and medical devices are completely successful. Failures or clinical complications are often observed, with different incidences related to the applications. The Research Proposal I am putting forward is a NSERC discovery program very solidly based and anchored on studying material science and engineering aspects applied to the cardiovascular medical field. Specifically, I propose to pursue and consolidate a new 3 blocks-research program for: 1) investigating the parameters allowing the development of a highly-adherent and strongly-cohesive coating mainly based on plasma polymerization for metallic devices; 2) designing a new class of degradable metals specific for cardiovascular devices; and 3) developing new strategies for interfacing materials and cells under mechanical stresses in specific controlled bioreactors for the regeneration of the vascular tissue. The overall goal of blocks 1 and 2 is to provide at short and medium terms (1 to 5 years) new coatings and new materials capable to improve the clinical performances of medical devices. The overall goal of block 3 is to produce targeted knowledge and expertise susceptible to generate at long terms (10 to 15 years) specific methodologies for the regeneration of the functional vascular tissue. The proposed research program is very pertinent and timed to answer the need of the formation of highly qualified personnel, thus fulfilling precise social needs, and medical-device industry challenges. Moreover, the proposed research program is planned to result in a polyvalent technological platform susceptible to be applied to other fields and applications, including pharmaceutical, corrosion-resistant, optical, domestic, military and industrial, where specifically-designed materials and coatings with targeted properties are required. We are engineering solutions to biomedical challenges using advanced materials science and engineering. In this proposal, we both advance knowledge and train high quality personnel in key areas of strength for Canada. Our research environment is exceptional and particularly adapted to the new global market era we are facing now. More than 100 HQP were trained in our laboratory since 2008: Today, they pursue positions in academia, industry and government by using daily advanced knowledge, leadership, fast adaptive skills, global network connections and strategic thinking for which they have been trained with us. Our Laboratory is recognised to publish widely and in opening new doors in Science, patent new inventions and propose licenses, present at international conferences, collaborate with some twenty world leaders in academia and industry in four continents, and provide advices to regulatory governmental agencies.