A universal palladium precatalyst for efficient chemical synthesis of molecules and materials

催化是化学合成中的一项使能技术，为有效制备新分子和新材料提供了手段，其应用范围从太阳能收集到人类健康。钯催化交叉偶联是最强大和最广泛使用的催化方法之一，特别是在工业研发中创造新的药物，农用化学品和有机材料。应用钯催化合成复杂分子靶标的一个重大挑战是确定钯源和辅助添加剂的适当组合；工业研究小组将进行成千上万的实验来解决这个问题。第二个主要挑战是在最大限度地降低货物成本的同时，大规模地实现所需产品的高化学产量。对于钯催化过程，这往往是一个微妙的平衡之间的效率最大化和最小化催化剂的量。我们的研究小组最近报道了一个强大而活跃的钯催化剂家族，用于实现碳碳，碳氮和碳氧键的形成。这套催化剂是专门设计用于实现和加速反应发现的高通量筛选，并且在放大和工艺优化过程中也便于用户使用。该提案旨在弥合我们的基础，实验室规模的见解之间的鸿沟，将这一发现转化为合成和制造新分子和材料的实用和商业化解决方案。最终，通过降低商品/制造成本，这将有助于降低药品和绿色能源设备的成本。

Catalysis is an enabling technology in chemical synthesis, providing the means to efficiently prepare new molecules and materials with applications ranging from solar energy harvesting to human health. Palladium-catalyzed cross-coupling is among the most powerful and widely used catalytic methods, particularly in industrial R&D to create new pharmaceuticals, agrochemicals, and organic materials. A significant challenge in applying palladium catalysis to synthesize complex molecular targets is identifying the appropriate combination of palladium source and supporting additives; industrial research groups will literally perform thousands of experiments to tackle this problem. A second major challenge is to achieve high chemical yield of the desired product on large scale while minimizing the cost of goods. For palladium catalyzed processes, this is often a delicate balance between maximizing efficiency and minimizing the catalyst amount.Our research group recently reported a robust and active family of palladium catalysts for achieving the formation of carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. This set of catalysts was designed specifically to enable and accelerate high-throughput screening for reaction discovery, and also to be user-friendly during scale-up and process optimization. This proposal seeks to bridge the divide between our fundamental, laboratory-scale insights to turn this discovery into a practical and commercialized solution for the synthesis and manufacture of new molecules and materials. Ultimately, this will help drive down the cost of medicines and green energy devices by reducing the cost of goods/manufacture.