Whole-Genome Analysis of Klebsiella pneumoniae Isolated from instances of Bovine Mastitis in Canada

肺炎克雷伯氏菌是一种细菌病原体，可引起人类和奶牛的严重感染。由于抗菌素耐药菌株的增加，它在人类和牛中变得越来越不可治疗。关于K之间的关系知之甚少。引起人类感染的肺炎菌株和引起奶牛感染的菌株。目前还不清楚是否有显着的传播来回之间的人和牛，或者如果完全不同的血统K。肺炎是人类和奶牛感染的原因。本研究将对来自加拿大和爱尔兰的各种牛和人分离株进行全基因组测序，并确定在这两个国家引起人和牛疾病的分离株的相关性。本研究所产生的知识将有助于开发管理实践以及非抗生素治疗和预防药物，以预防和治疗K。奶牛肺炎感染。它还将被用来为有用的公共政策和生物安全措施提供信息，以减少这一重要病原体的人畜共患病和反向人畜共患病转移。

Klebsiella pneumoniae is a bacterial pathogen that can cause serious infections in both humans and dairy cattle. It is becoming increasingly untreatable in both humans and cattle due to the rise in antimicrobial resistant strains. Very little is known about the relationships between the K. pneumoniae strains that cause human infections and the strains that cause infections in dairy cows. It is unclear if there is significant transmission back and fourth between humans and cows, or if completely distinct lineages of K. pneumoniae are responsible for infections in humans and cows. This study will whole genome sequence a variety of bovine and human isolates from both Canada and Ireland and determine how related the isolates causing illness in humans and cows are in both countries. The knowledge generated by this study will help to develop management practices as well as non-antibiotic therapeutics and prophylactics to prevent treat and prevent K. pneumoniae infections in dairy cattle. It will also be usedto inform useful public policy and biosecurity measures aimed at reducing zoonotic and reverse-zoonotic transfer of this important pathogen.