Innovative biomedical microsystems driven by data and artificial intelligence

这项研究计划结合了工程学、神经科学、辅助技术和生命科学，解决了生物医学技术领域中世界上最重要的问题，包括人类表现的提高、药物发现、大脑疾病和衰老。特别是，重点是创造新的方法，通过新的智能肌电假体来改善人类的表现，并用新的高精度工具加强实验神经科学研究。与加拿大智能生物医学微系统研究教席一起，这项研究将真正成为可能，并将推动加拿大走在国际科学舞台的前列。该计划将涵盖三个重要的研究目标：目标1)创建芯片边缘人工智能(AI)策略，以开发几乎为零延迟的闭环式脑部疗法；目标2)设计具有嵌入式人工智能的超高密度肌电控制器，提供回归控制；以及目标3)设计世界上最小的集成传感器，提供医疗级生命体征测量。应该指出的是，该计划的一个重要重点是利用机器学习技术开发传感器内智能，以避免延迟并提高目标3中的传感器精度。该计划的长期愿景是促进从医疗仪器、材料科学、人工智能和先进微系统制造中创造新的突破性技术，以提高生物医学系统的智能和功能，同时将其小型化推向前所未有的水平。另一个长期目标是继续为智能生物医学技术领域的各级研究人员发展一个优秀和包容性的培训环境。本申请中提出的研究具有极大的原创性和创新性，很可能通过在临床前研究、辅助技术和个性化医学方面取得突破性进展而产生影响。这一计划可能会带来解决紧迫社会经济需求的技术或政策，以开发针对情绪障碍的更好疗法，改善残疾人的生活质量，并有助于使个性化医疗成为现实。参与的学生将参加国际会议，展示他们的工作并建立他们的网络。他们将学习和开发新的先进技能，以应对生物医学技术和人工智能在开发具有附加价值的突破性设备方面的几个关键挑战。他们还将在多技术集成方面开发独特的专业知识，并将获得先进制造方面的实践经验，这些经验将在他们入职时或在研究期间或之后直接与最终用户互动时转移到加拿大行业。

This research program is at the interface of engineering, neuroscience, assistive technology and life sciences, and addresses the world's most important questions in the field of biomedical technologies, including human performance enhancement, drug discovery, brain diseases, and aging. In particular, the focus is on the creation of new approaches to improve human performance through new smart myoelectric prostheses, and to enhance experimental neuroscience research with novel high-precision tools. In conjunction with the Canada Research Chair in Smart Biomedical Microsystems, this research will be truly enabling and will propel Canada at the forefront of the international scientific scene. Three important research aims will be covered by this program: Aim 1) Create on-chip edge AI (artificial intelligence) strategies that will allow developing closed-loop brain therapies with nearly zero latency, Aim 2) Design ultra-high-density myoelectric controllers with embedded AI providing regressive control, and Aim 3) Design the world's smallest integrated sensors providing medical-grade vital signs measurement. It should be noted that an important focus of this program is on developing in-sensor intelligence drawing from machine learning techniques to avoid latency and enhance sensor precision in Aims 1 to 3. The long-term vision of the program is to foster the creation of new groundbreaking technology drawing from medical instrumentation, material science, AI and advanced microsystems manufacturing to increase biomedical systems intelligence and functionality while pushing their miniaturization to unprecedented levels. Another long-term objective is to continue developing an excellent and inclusive training environment for researchers at all levels in the field of intelligent biomedical technologies. The research proposed in this application is extremely original and innovative and is likely to have impact by leading to groundbreaking advances in preclinical research, assistive technology, and personalized medicine. This program will potentially lead to technologies or policies addressing urgent socio-economic needs to develop better therapeutics against mood disorders, improve the quality of life of people living with a disability and contribute to make personalized medicine becoming a reality. The students involved will participate to international conferences to present their work and building their network. They will learn and develop new advanced skills to address several key challenges in biomedical technology and AI towards the development of groundbreaking devices of added value. They will also develop unique expertise in multi-technology integration, and will gain practical experience in advanced manufacturing, which will be transferred to the Canadian industry when they will take positions, or when they will interact directly with end users during or after this research.