Characterisation of the novel mitochondrial protein (CABC1/ADCK3) and its role in protecting against oxidative stress

新型线粒体蛋白 (CABC1/ADCK3) 的表征及其在防止氧化应激中的作用

• 批准号: DP1092466
• 负责人: Prof Martin Lavin
• 金额: $ 20.85万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092466
• 关键词: Characterisation; novel; mitochondrial; protein; CABC1

This is the first detailed characterisation and mechanistic study on a protein that protects against oxidative stress and neurodegeneration. Demonstrating the basis for this oxidative stress and its possible contribution to the cellular phenotype will be of benefit in understanding the disease process and ultimately designing approaches to minimise oxidative stress. An investigation of this protein presents an opportunity for the investigator to work at the forefront in this field adding to Australia's scientific leadership in the area. It also represents an ideal project for post-graduate training and is a collaboration between groups in Brisbane and Melbourne.

这是第一次对一种防止氧化应激和神经退化的蛋白质进行详细的特征和机制研究。证明这种氧化应激的基础及其对细胞表型的可能贡献将有助于理解疾病的过程，并最终设计出将氧化应激降至最低的方法。对这种蛋白质的研究为研究人员提供了一个在这一领域走在前列的机会，增加了澳大利亚在该领域的科学领导地位。它也是研究生培训的理想项目，是布里斯班和墨尔本两地团体之间的合作。