To investigate the role of the protein kinase SMG-1 in the stress response

研究蛋白激酶 SMG-1 在应激反应中的作用

• 批准号: DP1092489
• 负责人: Prof Martin Lavin
• 金额: $ 19.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092489
• 关键词: investigate; role; protein; kinase; SMG

This project is included in the designated priority area of research Promoting and Maintaining Good Health and Ageing Well. It represents a mouse model to assist in the study of human disease. It is the first mouse model for SMG-1, a protein kinase that protects against a variety of different forms of stress. The strength of the model is that it can be combined with other mouse models to interrogate and elucidate the events occurring in different pathways for stress. The expectation is that ground-breaking data will be generated with this model providing scientific leadership on the role of this protein. It will also assist in establishing new collaborations.

该项目被列入指定的优先研究领域“促进和保持良好的健康和良好的老龄化”。它代表了一种小鼠模型，以协助研究人类疾病。这是SMG-1的第一个小鼠模型，SMG-1是一种蛋白激酶，可以防止各种不同形式的压力。该模型的优势在于，它可以与其他小鼠模型相结合，以询问和阐明在不同的应激途径中发生的事件。我们的期望是，该模型将产生突破性的数据，为这种蛋白质的作用提供科学领导。它还将协助建立新的合作关系。