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Co-ordinated Action of ATM and DNA-PK in DNA damage recognition

Co-ordinated Action of ATM and DNA-PK in DNA damage recognition
ATM 和 DNA-PK 在 DNA 损伤识别中的协调作用
批准号：
DP0346724
负责人：
Prof Martin Lavin
金额：
$15.71万
依托单位：
Queensland Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2003
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2003-01-01 至 2005-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP0346724
关键词：
CoordinatedActionATMDNA

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中文摘要
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英文摘要
The aim of this project is to investigate the mechanism of repair of double straind breaks in DNA sustained after radiation damage. Specifically we will focus on two proteins ATM (mutated in the genetic disorder ataxia-telangiectasia) and DNA-PK mutated in scid mice. There two proteins recognize double straind breaks in DNA and signal this damage to the DNA repair machinery of the cell and to cell cycle checkpoints. The emphasis here will be in the relationship between the two proteins in co-ordinating the repair of breaks in DNA. This information will be important in understanding mechanisms for maintaining the integrity of the genome.
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