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Role of Senataxin in protecting against neurodegeneration

Role of Senataxin in protecting against neurodegeneration
Senataxin 在预防神经退行性疾病中的作用
批准号：
nhmrc : 631407
负责人：
Prof Martin Lavin
金额：
$35.99万
依托单位：
The University of Queensland
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2010
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2010-01-01 至 2012-12-31
来源：
https://researchdata.edu.au/role-senataxin-protecting-neurodegeneration/95111
关键词：
RoleSenataxinprotectingagainstneurodegeneration

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英文摘要
A number of rare autosomal recessive ataxias have been described that overlap in their clinical phenotype. A subgroup of these have in common a reduced capacity to deal with damage to the genome which is associated with neurodegeneration. We are characterising the protein (senataxin) defective in one of these syndromes, ataxia oculomotor apraxia type 2 (AOA2). We have generated a mouse model of setx the gene coding for senataxin which will assist in our understanding of this disease.
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