Identification of functionally important autophosphorylation site(s) on ataxia telangiectasia and Rad 3 - related (ATR) protein kinase.

共济失调毛细血管扩张症和 Rad 3 相关 (ATR) 蛋白激酶上功能重要的自磷酸化位点的鉴定。

• 批准号: DP0666572
• 负责人: Prof Martin Lavin
• 金额: $ 18.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0666572
• 关键词: Identification; functionally; important; autophosphorylation; site

The integrity of our genetic material must be maintained so that it can be passed on from one generation to the next and also to minimize the risk of cancer and other pathologies in an individual. There are multiple proteins involved in protecting our DNA including several enzymes that detect and signal DNA damage to a series of pathways involved in halting the passage of cells through the cell cycle so that repair can occur. This project studies the mechanism of action of one of these enzymes which will be of benefit in designing new compounds to fight disease.

我们必须保持遗传物质的完整性，以便将其代代相传，并将个人患癌症和其他病理疾病的风险降至最低。有多种蛋白质参与保护我们的DNA，包括几种酶，它们检测DNA损伤并向一系列途径发出信号，这些途径涉及阻止细胞通过细胞周期，以便进行修复。该项目研究了其中一种酶的作用机制，这将有助于设计新的化合物来抗击疾病。