A novel role for SMG-1 protein kinase in stress granule formation and the stress response.
A novel role for SMG-1 protein kinase in stress granule formation and the stress response.
批准号:
DP0987005
负责人:
Prof Martin Lavin
金额:
$7.48万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2010-12-31
中文摘要
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英文摘要
Humans are constantly exposed to agents in the environment that threaten the integrity of their cells and increases the risk of cancer and other pathologies. Cells have developed repair mechanisms to cope with damage to their DNA and avoid long term effects. The emphasis in this application is to investigate the mechanisms by which stress affects the transcriptional machinery in the cell. A description of the processes involved will assist in understanding how specific disease states arise and will provide a means of devising compounds/drugs to assist the response to stress.
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