A novel role for SMG-1 protein kinase in stress granule formation and the stress response.

SMG-1 蛋白激酶在应激颗粒形成和应激反应中的新作用。

• 批准号: DP0987005
• 负责人: Prof Martin Lavin
• 金额: $ 7.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987005
• 关键词: novel; role; SMG; protein; kinase

Humans are constantly exposed to agents in the environment that threaten the integrity of their cells and increases the risk of cancer and other pathologies. Cells have developed repair mechanisms to cope with damage to their DNA and avoid long term effects. The emphasis in this application is to investigate the mechanisms by which stress affects the transcriptional machinery in the cell. A description of the processes involved will assist in understanding how specific disease states arise and will provide a means of devising compounds/drugs to assist the response to stress.

人类不断暴露于环境中的物质，这些物质威胁着细胞的完整性，增加了患癌症和其他疾病的风险。细胞已经开发出修复机制来科普DNA损伤并避免长期影响。本申请的重点是研究应激影响细胞转录机制的机制。对所涉及过程的描述将有助于理解特定疾病状态是如何产生的，并将提供一种设计化合物/药物以帮助应对压力的方法。