Microprobes for Characterization of Immobilized Cell Systems

本研究涉及用于固定化细胞系统表征的微探针的开发。固定细胞所处的环境与自由细胞截然不同，这可能会改变它们的代谢行为。由于实验技术的限制，对这种微环境效应的研究受到了限制。为了满足这一需求，该项目正在开发能够测量固定细胞附近氧化还原电位和重要细胞代谢物浓度的微探针。这些新的微探针将提供新的研究能力，这将大大扩大对固定化细胞系统的研究范围。

This study involves the development of microprobes for characterization of immobilized cell systems. Immobilized cells are in an environment which is drastically different from that of free cells, and this is likely to change their metabolic behavior. Studies on this microenvironmental effect have been constrained by the limitations of experimental techniques in micro-scale. To fill this need, this project is developing microprobes which are capable of measuring redox potential and the concentrations of important cellular metabolites in the immediate vicinity of the immobilized cells. These new microprobes will provide new research capabilities, which will significantly expand the scope of investigation into the immobilized cell systems.