Acquisition of a High-Resolution High-Mass Mass Spectrometer Complete with MS/MS Capabilities

该提案要求资金用于购买高分辨率高质谱计，完成MS/MS。该仪器将位于质谱仪中心，这是一个分析和生物分析资源，提供了最先进的质谱分析能力。具体而言，该文书将规定：精确的质量测量以提供未知有机化合物的元素组成，低分辨率的高质量范围扫描用于新开发的软电离方法，连接扫描用于分析亚稳，子离子和孙女离子和中性跃迁，作为辅助结构解析使用MS/MS。用户涉及土壤化感化学物质和腐殖质物质的研究、合成和机械有机化学、化石燃料和环烷酸的组成、质子亲和、植物抗菌素的生物合成、低聚物和多糖识别过程、蛋白质鉴定和基因克隆、聚合物网络结构、类维生素a的代谢和鉴定，液体燃料的加氢加工，真菌毒素的阐明，电子传递链和泛醌。该仪器也将被周围的质谱仪社区使用。

This proposal requests funds for the purchase of a high- resolution high-mass spectrometer complete with MS/MS. The instrument will be located in the mass spectrometer center, an analytical and bioanalytical resource that provides state-of-the- art capability in mass spectrometry. Specifically, the instrument will provide: exact mass measurements to provide elemental composition for unknown organic compounds, high- mass- range scanning at low resolution for use with newly developed soft ionization methods, and linked scans for the analysis of metastable, daughter, and granddaughter ions and neutral transitions as an aid to structure elucidation using MS/MS. The users are involved in research on allelochemicals and humic substances from soil, synthetic and mechanistic organic chemistry, composition of fossil fuels and naphthenic acids, proton affinity, biosynthesis of phytoalexins, oligo- and polysaccharide recognition process, protein identification and gene cloning, structures of polymer networks, metabolism and identification of retinoids, hydroprocessing of liquid fuels, elucidating fungal toxins, and electron transport chain and ubiquinones. The instrument will also be used by the surrounding community of mass spectrometrists.