Purchase of a Mass Spectrometer with Accessories

购买质谱仪及其附件

• 批准号: 8705697
• 负责人: Michael Hall
• 金额: $ 27.7万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8705697&HistoricalAwards=false
• 关键词: Purchase; Mass; Spectrometer; Accessories

Mass spectral techniques such as Electron Impact (EI), Chemical Ionization (CI) and Fast Atom Bombardment (FAB) are used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The acquisition of instrumentation capable of carrying out these state-of-the-art techniques is essential for the prosecution of frontier research in several fields of chemistry and biology. The purchase of an analytical high resolution mass spectrometer will be facilitated by support from the Chemistry Shared Instrumentation Program and the Biological Instrumentation Program. The areas of chemistry and biology that will be enhanced include: 1) Determination of Organic Structures and Reaction Mechanisms 2) Reaction Pathways in Polynuclear Metal Carbonyls 3) Stereoselective Synthesis and Characterization of Natural Products 4) Auto-oxidation of Cobalt Dioxygen Complexes 5) Mass Spectrometric Probes of Enzyme Structures and Mechanisms 6) Studies on the Dissociation Dynamics of Large Molecules 7) Applications of Mass Spectrometry to Biochemistry and Toxicology 8) Model Systems for Biological Oxidation Reactions 9) Characterization of Biologically Important Molecules

质谱技术，例如电子轰击（EI）、化学分析和质谱分析。 电离（CI）和快原子轰击（FAB）用于 探测其结构细节， 一系列有机、生物有机和 有机金属分子 仪器设备的购置 能够执行这些最先进的技术的是 在几个领域进行前沿研究至关重要， 化学和生物学领域。 购买分析型高分辨率质谱仪 将通过化学共享的支持来促进 仪器程序和生物仪器 程序. 化学和生物学领域， 增强的包括： 1)有机结构与反应的测定 机制 2)多核金属羰基化合物的反应途径 3)立体选择性合成与表征 天然产物 4)钴氧配合物的自氧化 5)酶结构和性质的质谱探针 机制 6)大分子解离动力学研究 7)质谱在生物化学和生物医学中的应用 毒理学 8)生物氧化反应模型系统 9)生物重要分子的表征