Acquisition of High Field NMR Spectrometer
Acquisition of High Field NMR Spectrometer
批准号:
0416157
负责人:
Viktor Zhdankin
金额:
$50.87万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-08-01 至 2007-07-31
中文摘要
得奖后,明尼苏达大学德卢斯分校化学系将获得一台500兆赫的核磁共振(核磁共振)光谱仪。该设备将使研究人员能够开展以下方面的研究:a)在有机、无机和有机金属合成研究中制备的相对较小的分子的表征;以及b)结构生化研究,如从天然产物中研究蛋白激酶抑制剂和阐明细胞色素c.核磁共振光谱是化学家可用于阐明分子结构的最强大的工具之一。它被用来识别未知物质,表征分子内原子的特定排列,并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说,获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成化学和生物化学产生影响。
英文摘要
With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of Minnesota in Duluth will acquire a 500 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) the characterization of relatively small molecules prepared in organic, inorganic and organometallic synthetic studies; and b) structural biochemical studies, such as the study of protein kinase inhibitors from natural products and the elucidation of the folding pathway of cytochrome c. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic chemistry and biochemistry.
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