Novel ultraviolet radiation filters from extreme environments

来自极端环境的新型紫外线辐射过滤器

• 批准号: DP190103314
• 负责人: Prof Brett Neilan
• 金额: $ 27.74万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-08-16 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103314
• 关键词: Novel; ultraviolet; radiation; filters; extreme

This project aims to exploit uncultured microorganisms to produce and characterise novel ultraviolet radiation-filter biosynthesis pathways. Current ultraviolet radiation-filtering compounds are toxic and persistent. There is a need for biodegradable, ultraviolet radiation filters that are safe for use across a variety of health and industrial applications. Over millions of years, the damaging effect of ultraviolet radiation has exerted selective pressure on organisms that has driven the evolutionary diversity of natural radiation-filtering compounds. This project expects to characterise and harness the microbial diversity of unique high ultraviolet radiation ecosystems via synthetic biology to produce industrially and pharmacologically useful ultraviolet radiation filters.

该项目旨在利用未培养的微生物来生产和表征新型紫外线辐射过滤生物合成途径。目前的紫外线辐射过滤化合物有毒且持久。需要可生物降解的紫外线辐射过滤器，可以安全地用于各种健康和工业应用。数百万年来，紫外线辐射的破坏作用对生物体施加了选择压力，从而推动了天然辐射过滤化合物的进化多样性。该项目期望通过合成生物学来表征和利用独特的高紫外线辐射生态系统的微生物多样性，以生产工业和药理学上有用的紫外线辐射过滤器。