The toxins of water-borne cyanobacteria: regulation and exploitation of their biosynthesis

水生蓝藻毒素：其生物合成的调控和开发

• 批准号: FF0883440
• 负责人: Prof Brett Neilan
• 金额: $ 117.9万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Federation Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FF0883440
• 关键词: toxins; water; borne; cyanobacteria; regulation

Water quality is a major concern in Australia, as is the global need for new natural products with antibiotic activity. The mechanisms by which cyanobacteria produce toxins that reduce the quality of water may very well be the answer to the lack of novel medicinal compounds currently being discovered in nature. Encompassed in this one program are the aims of ameliorating the effects of toxic algal blooms as well as introducing the means for the design and synthesis of a range of novel bioactive products. The benefits include better water quality and biosafety management options, a new generation of drug design and discovery, and the associated transformation of environmental and medical research and education in Australia.

水质是澳大利亚的一个主要问题，全球对具有抗生素活性的新型天然产品的需求也是如此。蓝藻产生降低水质的毒素的机制很可能是目前在自然界中发现的新型药用化合物缺乏的答案。该计划的目标是改善有毒藻华的影响以及介绍一系列新型生物活性产品的设计和合成方法。其好处包括更好的水质和生物安全管理方案、新一代药物设计和发现，以及澳大利亚环境和医学研究和教育的相关转型。