Synthetic Biology: from Genomics to Valuable Bioproducts

合成生物学：从基因组学到有价值的生物产品

• 批准号: LE200100016
• 负责人: Prof Brett Neilan
• 金额: $ 26.17万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-18 至 2021-06-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE200100016
• 关键词: Synthetic; Biology; Genomics; Valuable; Bioproducts

Genomics has led to the discovery of both the fine and gross characteristics of specific microbial physiologies. This project aims to take the genetic diversity inherent in microbial systems and exploit it for biotechnology applications, using the cutting-edge facilities available for synthetic biology. The acquisition of a long-read sequencing platform, droplet digital PCR machine, pulsed-field electrophoresis apparatus, DNA library system and small scale bioreactor will address the limitations of short-read sequencing, large fragment cloning and gene expression technologies, currently creating bottlenecks for synthetic biologists.

基因组学已经发现了特定微生物生理的细微和大体特征。该项目旨在利用合成生物学的尖端设施，利用微生物系统固有的遗传多样性，并将其用于生物技术应用。此次收购的长读段测序平台、液滴数字PCR机、脉冲场电泳仪、DNA文库系统和小型生物反应器将解决短读段测序、大片段克隆和基因表达技术的局限性，这些技术目前是合成生物学家的瓶颈。