Sodium homeostasis and the molecular basis for neurotoxin production by bacteria and algae

钠稳态以及细菌和藻类产生神经毒素的分子基础

• 批准号: DP0556484
• 负责人: Prof Brett Neilan
• 金额: $ 53.68万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-05-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0556484
• 关键词: Sodium; homeostasis; molecular; basis; neurotoxin

An understanding of the physiology of saxitoxin-producing microorgansims in response to salt stress is critical for the prevention of toxic blooms and for risk assessment of contaminated water bodies. This is nowhere more relevant than in the depleted and increasingly saline water resources of inland Australia. This project will develop genetic tests to assay for saxitoxin-producers and to monitor toxin production in response to the environment, representing an easier, more economic and ethical alternative to current tests. The market for this type of predictive test includes environmental, anti-bioterrorism and fishery organisations. These genes will also allow the bioengineering of novel therapeutic drugs based on neuroactive alkaloids.

了解产生石房蛤毒素的微生物对盐胁迫的生理反应对于防止有毒水华和污染水体的风险评估至关重要。这一点在澳大利亚内陆枯竭和日益咸化的水资源中尤为重要。该项目将开发基因测试来检测蛤蚌毒素产生者并监测环境中毒素的产生，这是当前测试的一种更简单、更经济和更道德的替代方案。这类预测测试的市场包括环境、反生物恐怖主义和渔业组织。这些基因也将允许基于神经活性生物碱的新型治疗药物的生物工程。