A novel platform for the biosynthesis of commercially valuable saxitoxins

具有商业价值的石房蛤毒素生物合成的新平台

• 批准号: LP200100537
• 负责人: Prof Brett Neilan
• 金额: $ 29.17万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-04-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP200100537
• 关键词: novel; platform; biosynthesis; commercially; valuable

Saxitoxins are potent microbial toxins, which pose a significant threat to food and water quality. Highly pure saxitoxins are required for environmental monitoring and studies of cell physiology. Certain analogues have also shown promise as long-lasting and non-addictive pain blockers. However, the procurement of these compounds from natural sources is convoluted and unsustainable. This project aims to use the latest synthetic biology techniques to characterise, modify and express saxitoxin biosynthesis pathways, thereby providing a sustainable source of toxin analogues of value to industry and research. This novel 'green technology' will benefit the environment, human health and the Australian economy.

石房蛤毒素是一种强有力的微生物毒素，对食品和水质构成重大威胁。环境监测和细胞生理学研究需要高纯度的石房蛤毒素。某些类似物也显示出作为持久和非成瘾性疼痛阻滞剂的前景。然而，从自然来源获取这些化合物是复杂和不可持续的。该项目旨在利用最新的合成生物学技术来改造、修饰和表达石房蛤毒素生物合成途径，从而为工业和研究提供具有价值的毒素类似物的可持续来源。这种新颖的“绿色技术”将有利于环境、人类健康和澳大利亚经济。