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A novel platform for the biosynthesis of commercially valuable saxitoxins

A novel platform for the biosynthesis of commercially valuable saxitoxins
具有商业价值的石房蛤毒素生物合成的新平台
批准号：
LP200100537
负责人：
Prof Brett Neilan
金额：
$29.17万
依托单位：
The University of Newcastle
依托单位国家：
澳大利亚
项目类别：
Linkage Projects
财政年份：
2021
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2021-04-01 至 2024-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/LP200100537
关键词：
novelplatformbiosynthesiscommerciallyvaluable

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中文摘要
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英文摘要
Saxitoxins are potent microbial toxins, which pose a significant threat to food and water quality. Highly pure saxitoxins are required for environmental monitoring and studies of cell physiology. Certain analogues have also shown promise as long-lasting and non-addictive pain blockers. However, the procurement of these compounds from natural sources is convoluted and unsustainable. This project aims to use the latest synthetic biology techniques to characterise, modify and express saxitoxin biosynthesis pathways, thereby providing a sustainable source of toxin analogues of value to industry and research. This novel 'green technology' will benefit the environment, human health and the Australian economy.
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国内基金
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