Upgrade and Acquisition of NMR Instrumentation

该奖项由学术研究基础设施计划 将帮助牛津大学化学系 亚利桑那州获得了一个500 MHz的光谱仪，将用于 以下研究调查： 1. 卟啉化合物的合成及溶液结构， 金属卟啉和血红素蛋白质; 抗磁性和顺磁性卟啉;以及57 Fe NMR 模型血红素和血红素蛋白。 2. 视觉蛋白质的多核核磁共振结构研究。 3. 肽类激素和神经递质的核磁共振研究。 4. 高分子设计与分子拓扑学。 5. 加氢脱氮催化剂的核磁共振研究 6. 13 C化学位移的构象依赖性 肽的固态NMR光谱。 7. 钼酶模型的固态95 Mo NMR研究。 8. 超分子组装体的NMR研究 件. 9. 糖苷类化合物的新方法：鞘糖脂和 O-连接糖肽。 10. 天然产物和新化合物的核磁共振结构测定 聚陶瓷和嵌段共聚物。 11. 溶菌酶结合断裂E和F亚位点的研究 含N-乙酰氨基葡萄糖胞壁酸。 12. 有机高分子化学. %%% 核磁共振（NMR）光谱是最多的 化学家可以用来阐明 分子的结构 它用于识别未知 物质，表征内部原子的特定排列 分子，并研究相互作用的动力学之间 溶液中的分子。 获得最先进的NMR 光谱测定法对化学家来说是必不可少的， 前沿研究 这些NMR研究的结果是 可用于聚合物和催化以及生物学等领域。

This award from the Academic Research Infrastructure Program will help the Department of Chemistry at the University of Arizona acquire a 500 MHz spectrometer which will be used in the following research investigations: 1. Synthesis and Solution Structure of Porphyrins, Metalloporphyrins, and Heme Proteins; CP/MAS NMR of Diamagnetic and Paramagnetic Porphyrins; and 57Fe NMR of Model Hemes and Heme Proteins. 2. Multinuclear NMR Structural Studies of Visual Proteins. 3. NMR Studies of Peptide Hormones and Neurotransmitters. 4. Polymer Design and Molecular Topology. 5. NMR Investigations of Hydrodenitrogenation (HDN) Catalysts. 6. Conformational Dependence of 13C Chemical Shifts in the Solid-State NMR Spectra of Peptides. 7. Solid-State 95Mo NMR Studies of Molybdoenzyme Models. 8. NMR Studies of Supramolecular Assemblies and Their Components. 9. New Methodolgy for Glycosides: Glycosphingolipids and O-Linked Glycopeptides. 10. NMR Structure Determinations of Natural Products and New Polycerams and Block Copolymers. 11. Probing the E and F Subsites of the Lysozyme Binding Cleft With N-Acetylglucosaminyl Muramic Acid. 12. Organic Polymer Chemistry. %%% Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.