Integration of Fourier Transform Nuclear Magnetic Resonance Spectroscopy into the Undergraduate Chemistry Curriculum

化学系正在购买一台高场FT-NMR 具有13 C和1H共振能力的光谱仪，用于 本科化学课程的改进。 一 特别努力整合学习的理论， 正式课程与本科生研究计划。 ~（13）C和~ 1H FT-NMR的基本原理与应用 光谱分析首次介绍了在大二有机 化学实验室课程，学生亲自使用 确定有机结构的新仪器。 年轻的- 高级实验室课程（物理化学，分析 生物化学和仪器分析）中心 傅立叶变换方法的技术方面和 13 C NMR和1H NMR光谱的应用 化学系统的定量测量技术。 具体的NMR实验包括测定 平衡常数，热力学性质，pKa值， 和取代基常数;以及酶动力学的研究， 立体定向反应，氢交换速率，和反应 机制等 13 C/1H FT-NMR光谱仪的使用还 提高学生自主学习的质量和数量 研究是课程的重要组成部分。

This Department of Chemistry is purchasing a high field FT-NMR spectrometer with 13C and 1H resonance capabilities for use in the improvement of the undergraduate chemistry curriculum. A particular effort is made to integrate the theory learned in formal courses with the undergraduate student research program. The basic principles and practice of 13C and 1H FT-NMR spectrometry are first introduced in the sophomore Organic Chemistry Laboratory courses where students personally use the new instrument to determine organic structures. The junior- senior laboratory courses (Physical Chemistry, Analytical Biochemistry, and Instrumental Analysis) center on the technical aspects of fourier transform methods and the applications of 13C NMR alongside 1H NMR spectroscopic techniques for quantitative measurements of chemical systems. Specific NMR experiments include the determination of equilibrium constants, thermodynamic properties, pka values, and substituent constants; and studies on enzyme kinetics, stereospecific reactions, hydrogen exchange rates, and reaction mechanisms. The use of the 13C/1H FT-NMR spectrometer also enhances the quality and quantity of student independent research which is an important component of the curriculum.