Development of human tissue-mimicking polymer gels for multimodal medical imaging phantoms

开发用于多模态医学成像模型的模仿人体组织的聚合物凝胶

• 批准号: 470607-2014
• 负责人: Naguib, Hani
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=564233
• 关键词: Development; human; tissue; mimicking; polymer

The proposed research will develop polymer-based materials to create a standardized, life-sized liver phantom that is compatible to various medical imaging modalities. the long-term objective of this proposed research is to develop a human tissue-mimicking phantom that can accurately calibrate the multimodal medical imaging devices such as Magnetic Resonance Imaging (MRI), and Computed Tomography (CT). This will serve as a crucial strategic research tool to accurately portray or anticipate response characteristics of real tissue under imaging process. It will also assist the development of a standard for the image acquisition strategies to compare and overlay the images obtained from each modality to detect small lesions. It can also be used for precise and effective pre-treatment or surgical procedures planning for radiation therapy to promote accurate diagnosis for cancer research. The optimization of imaging protocols would be based on robust experimental data rather than current standards based on rationalization of established clinical practice. This is in direct

拟议的研究将开发基于聚合物的材料，以创建一个标准化的，与各种医学成像模式兼容的真人大小的肝脏幻影。本研究的长期目标是开发一种人体组织模拟模型，该模型可以精确校准多模态医学成像设备，如磁共振成像（MRI）和计算机断层扫描（CT）。这将作为一个至关重要的战略研究工具，以准确地描绘或预测真实组织在成像过程中的反应特征。它还将有助于制定图像采集策略的标准，以比较和覆盖从每种模式获得的图像，以检测小病变。它还可以用于精确有效的放射治疗前治疗或外科手术计划，以促进癌症研究的准确诊断。成像方案的优化将基于可靠的实验数据，而不是基于现有临床实践合理化的现行标准。这是直接的