Studies of Sol-Gel Materials for Chromatography: Preliminary Investigations

这是为少数族裔研究员路易斯·科隆提供的研究规划拨款，他是纽约州立大学布法罗分校分析化学的新教员。在这项工作中，科隆教授将提出一项利用溶胶-凝胶化学合成改性色谱固定相的研究方案。这里，在玻璃或二氧化硅载体的形成过程中引入了通常用于修饰层析载体的烷基部分。与传统的色谱固定相相比，这些材料有望具有更好的水解稳定性。这项研究计划拨款支持路易斯科隆公司开发新材料的努力，作为分离各种化学物种的基础。与传统材料相比，这里开发的材料可以抵抗更广泛的苛刻溶液条件。潜在的应用包括生物技术、制药和环境重要性的分离。

This is a research planning grant for a minority investigator, Luis Colon, who is a new faculty member of analytical chemistry at the State University of New York at Buffalo. In this work, Professor Colon will develop a research proposal on the synthesis of modified chromatographic stationary phases using sol-gel chemistry. Here, the alkyl moieties normally used to modify chromatographic supports are introduced during the formation of the glass or silica support. These materials are expected to have better hydrolytic stability than conventional chromatographic stationary phases. This research planning grant supports the efforts of Luis Colon to develop new materials to serve as the basis for separation of a wide range of chemical species. The materials developed here may be resistant to a broader range of harsh solution conditions than the traditional materials. Potential applications include separations of biotechnological, pharmaceutical and environmental importance.