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Stationary Phases for Liquid Phase Separations

用于液相分离的固定相

基本信息

批准号：
1508105
负责人：
Luis Colon
金额：
$ 49万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2019-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1508105&HistoricalAwards=false
关键词：
Stationary Phases Liquid Phase Separations

项目摘要

With this award, the Chemical Measurement and Imaging Program in the Division of Chemistry is supporting Professor Luis A. Colon of the University at Buffalo to develop stable separation media based on highly crosslinked polymeric layers on silica for use in separation techniques in chemical analysis. Separation media are indispensable analytical tools in chemical analysis, which is itself central to the chemical, biological, and related sciences. The proposed crosslinked polymeric layers are designed to possess high chemical and physical stability, with the goal of improving upon currently used separation materials. The proposed research is targeting a universal platform on which different separation media could be prepared, opening up possibilities for their use in specific practical applications. Broader impacts are addressed through the education and training of graduate and undergraduate students, including members of traditionally underrepresented groups. Research on this project will provide skills in chemical analysis that are very useful for the modern-day workforce in the academic, pharmaceutical and industrial chemical sectors. Experiments will be developed for the undergraduate laboratory so that more students can experience an authentic research experience in this setting. The research project will exploit the chemistry of diazonium salts to assemble organic molecular entities on the surface of silica substrates, rendering materials with highly desirable properties for liquid chromatography (LC) and other separation techniques, dictated by the newly assembled layer on the material's surface. The strategy consists on attaching functionalized aryl groups on the silica surface, from which molecular layers will grow by means of diazonium chemistry, and then crosslinking the layers to create a highly stable polymer layer on the silica surface. During the different stages of optimizing the synthesis of the new layer on the silica surface, a systematic evaluation will be performed to assess the physical, chemical, and chromatographic properties of the material using a battery of techniques (e.g., Fourier transform infrared (FTIR) spectroscopy, elemental analysis, gas adsorption analysis, x-ray photoelectron spectroscopy, thermogravimetric analysis). LC will be used to examine the chromatographic performance of the newly synthesized materials. The assessment will include the use of standard published protocols that will provide information on the retentive behavior (i.e., selectivity) and stability of the materials under liquid chromatographic conditions. These investigations are part of a long-term research program focused on the study of new and improved materials for chemical analysis, particularly in chemical separations.

有了这个奖项，在化学系的化学测量和成像计划是支持教授路易斯A。布法罗大学的Colon开发了基于二氧化硅上的高度交联聚合物层的稳定分离介质，用于化学分析中的分离技术。分离介质是化学分析中不可或缺的分析工具，化学分析本身是化学，生物和相关科学的核心。所提出的交联聚合物层被设计为具有高的化学和物理稳定性，目的是改进目前使用的分离材料。拟议的研究旨在建立一个通用平台，在该平台上可以制备不同的分离介质，为它们在特定的实际应用中的使用开辟了可能性。更广泛的影响是通过对研究生和本科生，包括传统上代表性不足的群体的成员进行教育和培训来解决的。该项目的研究将提供化学分析技能，对学术，制药和工业化学部门的现代劳动力非常有用。将为本科实验室开发实验，以便更多的学生可以在这种环境中体验真实的研究体验。该研究项目将利用重氮盐的化学性质在二氧化硅基材表面组装有机分子实体，使材料具有非常理想的性能，用于液相色谱（LC）和其他分离技术，这取决于材料表面上新组装的层。该策略包括在二氧化硅表面上连接官能化的芳基基团，分子层将通过重氮化学生长，然后交联这些层以在二氧化硅表面上产生高度稳定的聚合物层。在优化二氧化硅表面上的新层的合成的不同阶段期间，将使用一系列技术（例如，傅里叶变换红外（FTIR）光谱、元素分析、气体吸附分析、x射线光电子光谱、热重分析）。LC将用于检查新合成材料的色谱性能。该评估将包括使用标准公布的方案，该方案将提供关于保持行为的信息（即，选择性）和材料在液相色谱条件下的稳定性。这些研究是长期研究计划的一部分，重点是研究用于化学分析的新材料和改进材料，特别是在化学分离中。