Stationary Phases for Liquid Phase Separations

化学系的化学测量和成像项目获得该奖项，支持布法罗大学的Luis A.Colon教授开发稳定的分离介质，该介质基于二氧化硅上高度交联的聚合层，用于化学分析中的分离技术。分离介质是化学分析中不可或缺的分析工具，而化学分析本身就是化学、生物和相关科学的核心。所提出的交联型聚合物层的设计具有高度的化学和物理稳定性，目的是改进目前使用的分离材料。拟议的研究目标是一个通用平台，在这个平台上可以制备不同的分离介质，从而为它们在具体的实际应用中的使用开辟了可能性。通过教育和培训研究生和本科生，包括传统上代表性不足的群体的成员，来解决更广泛的影响。对该项目的研究将提供化学分析方面的技能，这些技能对学术、制药和工业化学部门的现代劳动力非常有用。将为本科生实验室开发实验，让更多的学生在这种环境下体验真实的研究体验。该研究项目将利用重氮盐的化学原理在二氧化硅衬底表面组装有机分子实体，根据材料表面新组装的层的要求，提供具有非常理想的性能的材料，用于液相色谱(LC)和其他分离技术。该策略包括在二氧化硅表面连接官能化的芳基，分子层将通过重氮化学的方式生长，然后交联层在二氧化硅表面创建高度稳定的聚合物层。在优化二氧化硅表面新涂层合成的不同阶段，将使用一系列技术(例如，傅立叶变换红外光谱(FTIR)、元素分析、气体吸附分析、X射线光电子能谱、热重分析)，对材料的物理、化学和色谱性能进行系统评估。将用LC检测新合成材料的层析性能。评估将包括使用标准公布的方案，这些方案将提供有关材料在液相色谱条件下的保留行为(即选择性)和稳定性的信息。这些研究是一个长期研究计划的一部分，该计划的重点是研究用于化学分析的新的和改进的材料，特别是在化学分离中。

With this award, the Chemical Measurement and Imaging Program in the Division of Chemistry is supporting Professor Luis A. Colon of the University at Buffalo to develop stable separation media based on highly crosslinked polymeric layers on silica for use in separation techniques in chemical analysis. Separation media are indispensable analytical tools in chemical analysis, which is itself central to the chemical, biological, and related sciences. The proposed crosslinked polymeric layers are designed to possess high chemical and physical stability, with the goal of improving upon currently used separation materials. The proposed research is targeting a universal platform on which different separation media could be prepared, opening up possibilities for their use in specific practical applications. Broader impacts are addressed through the education and training of graduate and undergraduate students, including members of traditionally underrepresented groups. Research on this project will provide skills in chemical analysis that are very useful for the modern-day workforce in the academic, pharmaceutical and industrial chemical sectors. Experiments will be developed for the undergraduate laboratory so that more students can experience an authentic research experience in this setting. The research project will exploit the chemistry of diazonium salts to assemble organic molecular entities on the surface of silica substrates, rendering materials with highly desirable properties for liquid chromatography (LC) and other separation techniques, dictated by the newly assembled layer on the material's surface. The strategy consists on attaching functionalized aryl groups on the silica surface, from which molecular layers will grow by means of diazonium chemistry, and then crosslinking the layers to create a highly stable polymer layer on the silica surface. During the different stages of optimizing the synthesis of the new layer on the silica surface, a systematic evaluation will be performed to assess the physical, chemical, and chromatographic properties of the material using a battery of techniques (e.g., Fourier transform infrared (FTIR) spectroscopy, elemental analysis, gas adsorption analysis, x-ray photoelectron spectroscopy, thermogravimetric analysis). LC will be used to examine the chromatographic performance of the newly synthesized materials. The assessment will include the use of standard published protocols that will provide information on the retentive behavior (i.e., selectivity) and stability of the materials under liquid chromatographic conditions. These investigations are part of a long-term research program focused on the study of new and improved materials for chemical analysis, particularly in chemical separations.