Silica-Based Hybrid Media for Chromatographic Applications

该奖项授予纽约州立大学布法罗分校的路易斯·科隆教授，由化学学部的分析和表面化学项目提供支持。本文主要研究了用于高效液相色谱（HPLC）和毛细管电色谱（CEC）的硅基有机-无机杂化材料的合成和表征。将烷氧基硅烷与可水解的烷氧基共聚合成二氧化硅杂化体。这种方法可以生产出不同形式的色谱材料（即薄膜、整体和颗粒），其中一些具有在宽pH范围内稳定的潜力。溶液化学将用核磁共振监测；利用ESCA、SIMS、FTIR、SEM和/或TEM、微量天平重量分析和氮气吸附方法评估有机-无机杂化物的物理化学特性。提出的研究方向是二氧化硅玻璃的合成和表征。可合成不同格式的物料，适用于化学分离。研究了制备过程中使用的不同参数，以确定反应条件，从而使材料具有最佳性能。合成玻璃的特性和成分将使用各种光谱和物理探针进行评估。诸如此类的制造材料在从制药到环境领域的大量化学品的分离和纯化方面具有潜在的应用。这些研究是长期研究计划的一部分，重点是开发和研究用于液相化学分离的新型和改进的材料。该研究项目主要由研究生和本科生参与实验，为新一代科学家的教育、发展和培训做出贡献。

This award to Professor Luis Colon of the SUNY at Buffalo is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. The proposed investigations are focused on the synthesis and characterization of silica-based organic-inorganic hybrid materials for use in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica hybrids will be synthesized by copolymerizing alkoxysilanes with hydrolyzable alkoxide groups. This approach results in the production of chromatographic materials in different formats (i.e., films, monoliths, and particles), some with the potential for stability over a wide pH range. The solution chemistry will be monitored with NMR; the physicochemical characteristics of the organic-inorganic hybrids will be assessed using ESCA, SIMS, FTIR, SEM and/or TEM, microbalance gravimetric analysis, and nitrogen gas adsorption methods. The proposed investigations are directed toward the synthesis and characterization of silica glasses. Different formats of the material will be synthesized, suitable for chemical separations. The different parameters used during the fabrication process will be studied to establish the reaction conditions leading to materials with the best performance. The characteristics and compositions of the synthesized glasses will be assessed using a variety of spectroscopic and physical probes. Fabricated materials such as these have potential applications to the separation and purification of a large number of chemicals, ranging from pharmaceutical to environmental areas. These investigations are part of a long-term research program focused on the development and study of new and improved materials for chemical separations in the liquid phase. The research program mainly involves graduate and undergraduate in executing the experimentation, contributing to the education, development, and training of a new generation of scientists.