Silica-Based Hybrid Media for Chromatographic Applications

用于色谱应用的二氧化硅基混合介质

• 批准号: 0138114
• 负责人: Luis Colon
• 金额: $ 41.3万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138114&HistoricalAwards=false
• 关键词: Silica; Based; Hybrid; Media; Chromatographic

This award to Professor Luis Colon of the SUNY at Buffalo is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. The proposed investigations are focused on the synthesis and characterization of silica-based organic-inorganic hybrid materials for use in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica hybrids will be synthesized by copolymerizing alkoxysilanes with hydrolyzable alkoxide groups. This approach results in the production of chromatographic materials in different formats (i.e., films, monoliths, and particles), some with the potential for stability over a wide pH range. The solution chemistry will be monitored with NMR; the physicochemical characteristics of the organic-inorganic hybrids will be assessed using ESCA, SIMS, FTIR, SEM and/or TEM, microbalance gravimetric analysis, and nitrogen gas adsorption methods. The proposed investigations are directed toward the synthesis and characterization of silica glasses. Different formats of the material will be synthesized, suitable for chemical separations. The different parameters used during the fabrication process will be studied to establish the reaction conditions leading to materials with the best performance. The characteristics and compositions of the synthesized glasses will be assessed using a variety of spectroscopic and physical probes. Fabricated materials such as these have potential applications to the separation and purification of a large number of chemicals, ranging from pharmaceutical to environmental areas. These investigations are part of a long-term research program focused on the development and study of new and improved materials for chemical separations in the liquid phase. The research program mainly involves graduate and undergraduate in executing the experimentation, contributing to the education, development, and training of a new generation of scientists.

该奖项授予纽约州立大学布法罗分校的Luis Colon教授，由化学部的分析和表面化学项目支持。建议的调查集中在硅基有机-无机杂化材料的合成和表征用于高效液相色谱（HPLC）和毛细管电色谱（CEC）。 二氧化硅杂化物将通过使烷氧基硅烷与可水解的醇盐基团共聚来合成。该方法导致不同形式的色谱材料的生产（即，膜、整料和颗粒），一些具有在宽pH范围内稳定的潜力。将使用NMR监测溶液化学;将使用ESCA、西姆斯、FTIR、SEM和/或TEM、微量天平重量分析和氮气吸附方法评估有机-无机杂化物的物理化学特性。 建议的调查是针对二氧化硅玻璃的合成和表征。将合成不同形式的材料，适用于化学分离。 将研究在制造过程中使用的不同参数，以建立产生具有最佳性能的材料的反应条件。 合成玻璃的特性和组成将使用各种光谱和物理探针进行评估。诸如这些的制造材料具有分离和纯化大量化学品的潜在应用，范围从制药到环境领域。这些调查是长期研究计划的一部分，该计划专注于开发和研究用于液相化学分离的新材料和改进材料。 该研究计划主要涉及研究生和本科生在执行实验，有助于教育，发展和培养新一代科学家。