Silica-Based Hybrid Media for Chromatographic Applications

该奖项授予纽约州立大学布法罗分校的路易斯·科隆教授，该奖项由化学部的分析和表面化学项目支持。本论文主要研究了硅基有机-无机杂化材料的合成和表征，主要用于高效液相色谱和毛细管电色谱。通过烷氧基硅烷与可水解醇氧基的共聚反应合成二氧化硅杂化材料。这种方法产生了不同格式的层析材料(即薄膜、整体和颗粒)，其中一些可能在很宽的pH范围内保持稳定。将使用核磁共振监测溶液化学；将使用ESCA、SIMS、FTIR、扫描电子显微镜和/或电子显微镜、微天平重量分析和氮气吸附方法评估有机-无机杂化材料的物理化学特性。拟议的研究是针对二氧化硅玻璃的合成和表征。不同格式的材料将被合成，适合化学分离。将研究制备过程中使用的不同参数，以建立导致材料具有最佳性能的反应条件。合成玻璃的特性和组成将使用各种光谱和物理探测器进行评估。这种合成材料在从制药到环境领域的大量化学品的分离和提纯方面具有潜在的应用。这些研究是一项长期研究计划的一部分，该计划的重点是开发和研究用于液体中化学分离的新的和改进的材料。研究计划主要由研究生和本科生参与执行实验，为新一代科学家的教育、发展和培养做出贡献。

This award to Professor Luis Colon of the SUNY at Buffalo is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. The proposed investigations are focused on the synthesis and characterization of silica-based organic-inorganic hybrid materials for use in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica hybrids will be synthesized by copolymerizing alkoxysilanes with hydrolyzable alkoxide groups. This approach results in the production of chromatographic materials in different formats (i.e., films, monoliths, and particles), some with the potential for stability over a wide pH range. The solution chemistry will be monitored with NMR; the physicochemical characteristics of the organic-inorganic hybrids will be assessed using ESCA, SIMS, FTIR, SEM and/or TEM, microbalance gravimetric analysis, and nitrogen gas adsorption methods. The proposed investigations are directed toward the synthesis and characterization of silica glasses. Different formats of the material will be synthesized, suitable for chemical separations. The different parameters used during the fabrication process will be studied to establish the reaction conditions leading to materials with the best performance. The characteristics and compositions of the synthesized glasses will be assessed using a variety of spectroscopic and physical probes. Fabricated materials such as these have potential applications to the separation and purification of a large number of chemicals, ranging from pharmaceutical to environmental areas. These investigations are part of a long-term research program focused on the development and study of new and improved materials for chemical separations in the liquid phase. The research program mainly involves graduate and undergraduate in executing the experimentation, contributing to the education, development, and training of a new generation of scientists.