Upgrade of 500 MHz Console

500 MHz 控制台升级

• 批准号: 9530429
• 负责人: Ming-Daw Tsai
• 金额: $ 25.8万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9530429&HistoricalAwards=false
• 关键词: Upgrade; 500; MHz; Console

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Ohio State University to acquire an upgrade of the console of an existing 500 MHz NMR spectrometer. This equipment will enhance research in a number of areas including the following: (1) The structure-function relationship of tumor suppressors, (2) Perforin-mediated cytolysis, (3) Chemistry and biochemistry of Vitamin A and its metabolites, (4) Reactions via ion-paired transition states, (5) Structure/property relationships in inorganic oxide glasses, (6) NMR conformational studies of glycosidase inhibitors, and (7) Compact domains in proteins. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will be useful in areas such as polymers, catalysis, and biology.

化学研究仪器和设施计划的这一奖项将帮助俄亥俄州州立大学化学系获得现有500 MHz NMR光谱仪控制台的升级。 该设备将加强多个领域的研究，包括以下领域：（1）肿瘤抑制剂的结构-功能关系，（2）穿孔素介导的细胞溶解，（3）维生素A及其代谢物的化学和生物化学，（4）通过离子配对过渡态的反应，（5）无机氧化物玻璃中的结构/性质关系，（6）糖苷酶抑制剂的核磁共振构象研究，和（7）蛋白质中的紧凑结构域。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。 它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。 这些NMR研究的结果将在聚合物、催化和生物学等领域有用。