Trigeminale Modulation der olfaktorischen Signalverarbeitung

嗅觉信号处理的三叉神经调制

• 批准号: 121896775
• 负责人: Professor Dr. Stephan Frings
• 金额: --
• 依托单位: Zelluläre Biophysik (ICS-4) (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/121896775?language=en
• 关键词: Trigeminale; Modulation; der; olfaktorischen; Signalverarbeitung

It has been known for many years that the two nasal chemosensory systems, the olfactory system and the trigeminal system, influence each other's sensory performance. Although well documented in numerous psychophysical studies, the cellular basis of this cross-modal interaction is not understood. Our project aims to elucidate the cellular mechanisms of this phenomenon in the two initial stages of the sense of smell, the olfactory epithelium and the olfactory bulb. Based on neuroanatomical, physiological, and psychophysical experimentation, we have identified three lines of evidence that point to an involvement of the trigeminal system in the formation of odour memory. (1) The trigeminal system specifically targets those structures in the olfactory epithelium and bulb that are involved in the processing of acquired olfactory information, as opposed to structures that mediate innate odour responses; (2) in rats, this innervation develops postnatally, indicating its focus on information processing in the mature animal; (3) in humans, the formation of odour memory is supported by costimulation of the nasal trigeminal system. These consistent sets of results indicate that olfactory performance is co-determined by the neuromodulatory impact of the trigeminal system onto the initial stages of information processing in olfactory eptihelium and olfactory bulb. Our project is designed to examine this concept on the celluar, systemic and cognitive levels of sensory processing.

多年来，人们已经知道，两个鼻腔化学感觉系统，嗅觉系统和三叉神经系统，相互影响的感觉性能。尽管在许多心理物理研究中有充分的记录，但这种跨模式相互作用的细胞基础尚不清楚。我们的项目旨在阐明这一现象的细胞机制在嗅觉的两个初始阶段，嗅上皮和嗅球。基于神经解剖学、生理学和心理物理学的实验，我们已经确定了三叉神经系统参与气味记忆形成的三条证据。(1)三叉神经系统专门针对嗅觉上皮和嗅球中参与获得性嗅觉信息处理的结构，而不是介导先天气味反应的结构；(2)在大鼠中，该神经支配在出生后发育，表明其在成熟动物中专注于信息处理；(3)在人类中，气味记忆的形成是由鼻三叉神经系统的共同刺激支持的。这些一致的结果表明，嗅觉表现是由三叉神经系统对嗅上皮和嗅球信息处理初始阶段的神经调节影响共同决定的。我们的项目旨在从感觉处理的细胞、系统和认知层面来检验这一概念。