Function of adult generated olfactory bulb interneurons

成年嗅球（OB）经历了一个连续的重塑的方式整合新生的中间神经元，主要是肾小球神经元（GN）和颗粒细胞（GC），而主二尖瓣和簇状细胞保持稳定。这些成人出生的中间神经元在OB网络中的功能尚未完全了解。这些interneurons表现出相当大的多样性，就其最终目的地在OB电路，他们的递质身份和神经化学性质表明，他们发挥不同的功能。在这里，我们提出了一个共同的努力，以分析负责成人产生的OB中间神经元的规格和他们的生理特性的分子机制，以更好地了解他们独特的贡献嗅觉处理。我们的目标尤其是：（i）理解GN的多巴胺能亚类的功能作用和调节其周转的分子机制，以及（ii）使用新的追踪技术表征成人产生的神经元与其他OB中间神经元（特别是GN）的突触连接。

The adult olfactory bulb (OB) undergoes a continuous remodelling by way of integration of new-born interneurons, mainly glomerular neurons (GNs) and granule cells (GCs), whereas the principal mitral and tufted cells remain stable. The function of these adult-born interneurons in the OB network is not yet fully understood. These interneurons exhibit substantial diversity with respect to their final destination within the OB circuitry, their transmitter identity and neurochemical properties suggesting that they exert different functions. Here we propose a combined effort to analyse the molecular mechanisms responsible for the specification of adult generated OB interneurons and their physiological properties, in order to better understand their unique contribution to olfactory processing. In particular we aim at: (i) understanding the functional role of the dopaminergic subclass of GNs and the molecular mechanisms regulating their turnover and (ii) characterizing the synaptic connectivity of adult-generated neurons with other OB interneurons, in particular GNs, using novel tracing techniques.