Function of adult generated olfactory bulb interneurons

成人产生的嗅球中间神经元的功能

• 批准号: 122410341
• 负责人: Professorin Dr. Veronica Egger
• 金额: --
• 依托单位: Institut für Zoologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/122410341?language=en
• 关键词: Function; adult; generated; olfactory; bulb

The adult olfactory bulb (OB) undergoes a continuous remodelling by way of integration of new-born interneurons, mainly glomerular neurons (GNs) and granule cells (GCs), whereas the principal mitral and tufted cells remain stable. The function of these adult-born interneurons in the OB network is not yet fully understood. These interneurons exhibit substantial diversity with respect to their final destination within the OB circuitry, their transmitter identity and neurochemical properties suggesting that they exert different functions. Here we propose a combined effort to analyse the molecular mechanisms responsible for the specification of adult generated OB interneurons and their physiological properties, in order to better understand their unique contribution to olfactory processing. In particular we aim at: (i) understanding the functional role of the dopaminergic subclass of GNs and the molecular mechanisms regulating their turnover and (ii) characterizing the synaptic connectivity of adult-generated neurons with other OB interneurons, in particular GNs, using novel tracing techniques.

成年嗅球(OB)通过新生中间神经元(主要是肾小球神经元和颗粒细胞)的整合进行持续的改建，而主要的二尖瓣细胞和簇状细胞保持稳定。这些成年出生的中间神经元在OB网络中的功能尚不完全清楚。这些中间神经元在其在OB回路中的最终目的地、它们的递质特性和神经化学特性方面表现出相当大的多样性，表明它们发挥着不同的功能。为了更好地理解成体OB中间神经元在嗅觉加工中的独特贡献，我们提出了一个联合努力来分析成体产生的OB中间神经元及其生理特性的分子机制。特别是，我们的目标是：(I)了解GNS的多巴胺能亚类的功能作用和调节其周转的分子机制；(Ii)利用新的示踪技术，表征成年产生的神经元与其他OB中间神经元，特别是GNS的突触连接。

项目成果

Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells

• DOI: 10.1016/j.neuron.2014.12.051
• 发表时间: 2015-02-04
• 期刊: NEURON
• 影响因子: 16.2
• 作者: Bywalez, Wolfgang G.;Patirniche, Dinu;Egger, Veronica
• 通讯作者: Egger, Veronica

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

• DOI: 10.1038/nn.3963
• 发表时间: 2015-04-01
• 期刊: NATURE NEUROSCIENCE
• 影响因子: 25
• 作者: Calzolari, Filippo;Michel, Julia;Ninkovic, Jovica
• 通讯作者: Ninkovic, Jovica

Dendritic Arborization Patterns of Small Juxtaglomerular Cell Subtypes within the Rodent Olfactory Bulb

• DOI: 10.3389/fnana.2016.00127
• 发表时间: 2017-01-20
• 期刊: FRONTIERS IN NEUROANATOMY
• 影响因子: 2.9
• 作者: Bywalez, Wolfgang G.;Ona-Jodar, Tiffany;Egger, Veronica
• 通讯作者: Egger, Veronica