Asymmetric Catalysis with Organotrichlorosilanes and Chiral Lewis Bases

这项工作围绕两个主题展开。第一类是探索手性Lewis碱催化的有机三氯硅烷反应的范围，包括羰基加成、亚胺加成、Michael加成、环氧化物开环和周环反应。第二个涉及催化不对称羟醛缩合反应的可能性的详细开发，主要涉及烯醇、醛和手性磷酰胺组分的多样性。通过这个续展奖项，有机和高分子化学项目支持伊利诺伊大学化学系的Scott E.Denmark博士的研究。丹麦教授将专注于开发在手性路易斯碱催化下的不对称转化中使用有机三氯硅烷的合成方法学。该化学代表了形成碳-碳键的重要方法。

This work centers on two themes. The first involves exploration of the scope of chiral Lewis-base-catalyzed reactions of organotrichlorosilanes including carbonyl additions, imine addition, Michael addition, epoxide opening and pericyclic reactions. The second involves a detailed development of the potential for catalytic asymmetric aldol reactions which primarily concerns the diversity of enolate, aldehyde and chiral phosphoramide components. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott E. Denmark of the Department of Chemistry at the University of Illinois. Professor Denmark will focus his work on developing synthetic methodology using organotrichlorosilanes in asymmetric transformations under catalysis by chiral Lewis bases. The chemistry represents an important methodology for the formation of carbon-carbon bonds.