Synthetic and Mechanistic Studies on Catalytic Asymmetric Reaction of Organosilanes

有机硅烷催化不对称反应的合成及机理研究

• 批准号: 9500397
• 负责人: Scott Denmark
• 金额: $ 42.75万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9500397&HistoricalAwards=false
• 关键词: Synthetic; Mechanistic; Studies; Catalytic; Asymmetric

The focus of this research is the use of silacyclobutane based reagents and chiral Lewis bases. The common theme is the pursuit of hexacoordinate silicon species as organizational nodes for bringing together combinations of nucleophile, electrophile and chiral catalyst for asymmetric transformations. Enoxysilacyclobutanes will be used to promote aldol, Michael, Henry and Abramov reactions and silacyclobutanes will be used in a broad range of organosilicon transformations. Another part of the research focuses on ligand-accelerated catalysis by the use of trichlorosilyl-based reagents. With this accomplishment based renewal award, the Synthetic Organic Program is supporting the research of Dr. Scott E. Denmark of the Department of Chemistry at the University of Illinois. Professor Denmark will focus his work on developing new methodology for catalytic, asymmetric transformations. The research will involve organosilicon compounds and chiral Lewis bases that possess hexacoordinate silicon species as the key component.

本研究的重点是基于硅杂环丁烷的试剂和手性路易斯碱的使用。 共同的主题是追求六配位硅物种作为组织节点，将亲核试剂、亲电试剂和手性催化剂的组合结合在一起，以实现不对称转化。 烯氧基硅杂环丁烷将用于促进羟醛、迈克尔、亨利和阿布拉莫夫反应，硅杂环丁烷将用于广泛的有机硅转化。 该研究的另一部分重点是使用三氯甲硅烷基试剂进行配体加速催化。 凭借这一基于成就的续奖，合成有机项目正在支持伊利诺伊大学化学系 Scott E.丹麦博士的研究。 丹麦教授的工作重点是开发催化、不对称转化的新方法。 该研究将涉及以六配位硅物质为关键成分的有机硅化合物和手性路易斯碱。