Synthetic and Mechanistic Studies on Catalytic Asymmetric Reaction of Organosilanes

本研究的重点是硅环丁烷基试剂和手性Lewis碱的使用。共同的主题是追求六配位硅物种作为组织节点，将亲核、亲电和手性催化剂的组合聚集在一起进行不对称转化。环氧硅环丁烷将用于促进Aldol、Michael、Henry和Abramov反应，硅环丁烷将用于广泛的有机硅转化。研究的另一部分重点是使用基于三氯硅基的试剂进行配体加速催化。通过这项以成就为基础的续展奖项，合成有机计划正在支持伊利诺伊大学化学系的斯科特·E·丹麦博士的研究。丹麦教授将把工作重点放在开发催化不对称转化的新方法上。这项研究将涉及有机硅化合物和具有六配位硅物种的手性Lewis碱作为关键成分。

The focus of this research is the use of silacyclobutane based reagents and chiral Lewis bases. The common theme is the pursuit of hexacoordinate silicon species as organizational nodes for bringing together combinations of nucleophile, electrophile and chiral catalyst for asymmetric transformations. Enoxysilacyclobutanes will be used to promote aldol, Michael, Henry and Abramov reactions and silacyclobutanes will be used in a broad range of organosilicon transformations. Another part of the research focuses on ligand-accelerated catalysis by the use of trichlorosilyl-based reagents. With this accomplishment based renewal award, the Synthetic Organic Program is supporting the research of Dr. Scott E. Denmark of the Department of Chemistry at the University of Illinois. Professor Denmark will focus his work on developing new methodology for catalytic, asymmetric transformations. The research will involve organosilicon compounds and chiral Lewis bases that possess hexacoordinate silicon species as the key component.